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. 2021 May 27;21(1):163.
doi: 10.1186/s12871-021-01378-7.

Aluminium release and fluid warming: provocational setting and devices at risk

Affiliations

Aluminium release and fluid warming: provocational setting and devices at risk

Thorsten Perl et al. BMC Anesthesiol. .

Abstract

Background: Fluid warming, recommended for fluid rates of > 500 ml h-1, is an integral part of patient temperature management strategies. Fluid warming devices using an uncoated aluminium containing heating element have been reported to liberate aluminium resulting in critical aluminium concentrations in heated fluids. We investigated saline solution (0.9%), artificially spiked with organic acids to determine the influence of fluid composition on aluminium release using the uncoated enFlow® device. Additionally, the Level1® as a high volume fluid warming device and the ThermoSens® device were investigated with artificial spiked fluid at high risk for aluminum release and a clinically used crystalloid solution.

Results: Saline solution spiked with lactate more than acetate, especially at a non neutral pH, led to high aluminium release. Next to the enFlow® device, aluminium release was observed for the Level1® device, but not for the coated ThermoSens®-device.

Conclusion: Uncoated aluminium containing fluid warming devices lead to potentially toxic levels of aluminium in heated fluids, especially in fluids with non-neutral pH containing organic acids and their salts like balanced electrolyte solutions.

Keywords: Fluid warming; Hypothermia; Prevention; Warming techniques.

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Conflict of interest statement

T.P. received consulting honorary from The 37Company The Netherlands and Barkey, Germany. A.B. received in the last years consulting honorary from 3 M Germany and honorary from The 37Company The Netherlands. M.Q., N.K.S., T.R., K.K. and U.T. declare no competing interests.

Figures

Fig. 1
Fig. 1
Mean (SD) aluminium concentration over the time (BL – Baseline; 0 to 60 min; each six measurements) for the enFlow® (Vital Signs, Inc., aGE Healthcare Company, Totowa New Jersey, USA) with different fluids as follows: ① saline 0.9 % ② saline 0.9 % with 50 mmol acetate ③ saline 0.9 % with 50 mmol lactate ④ saline 0.9 % with 50 mmol lactate at pH 4.0 ⑤ saline 0.9 % with 50 mmol lactate at pH 9 ⑥ saline 0.9 % at pH 9. Each six measurements
Fig. 2
Fig. 2
Mean (SD) aluminium concentration over the time (BL – Baseline; 0 to 60 min; each six measurements) for the Level 1® (H-1025 and DI-300 disposable, Smith medical, Minneapolis, USA) with different fluids as follows: ⑦ saline 0.9 % with 50 mmol lactate ⑧ saline 0.9 % with 50 mmol lactate at pH 9
Fig. 3
Fig. 3
Mean (SD) aluminium concentration over the time (BL – Baseline; 0 to 60 min; each six measurements) with balanced electrolyte solution Sterofundin 1/1 E ISO: ⑨ EnFlow® (Vital Signs, Inc., aGE Healthcare Company, Totowa New Jersey, USA) ⑩ Level 1® (H-1025 and DI-300 disposable, Smith medical, Minneapolis, USA)

References

    1. NICE: Hypothermia: prevention and management in adults having surgery. Clinical guideline [CG65]. In: NICE Clinical Guideline. https://www.nice.org.uk/guidance/cg65: NICE Clinical Guideline; 2016.
    1. Torossian A, Brauer A, Hocker J, Bein B, Wulf H, Horn EP. Preventing inadvertent perioperative hypothermia. Dtsch Arztebl Int. 2015;112(10):166–172. - PMC - PubMed
    1. Taylor MH, Choi D, Fitzpatrick SM, Gunn KN. Characterisation of aluminium release by the enFlow(R) fluid-warming system in crystalloids and blood products. Anaesthesia. 2019;74(11):1374–1380. doi: 10.1111/anae.14697. - DOI - PubMed
    1. Perl T, Kunze-Szikszay N, Brauer A, Quintel M, Rohrig AL, Kerpen K, Telgheder U. Aluminium release by coated and uncoated fluid-warming devices. Anaesthesia. 2019;74(6):708–713. doi: 10.1111/anae.14601. - DOI - PubMed
    1. (DIN) DIfN: Chemical analysis - Decision limit, detection limit and determination limit under repeatability conditions - terms methods, evaluation. In: DIN 32645:vol. 32645; 2008.

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