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Review
. 2021 Jun 1;77(21):2680-2692.
doi: 10.1016/j.jacc.2021.01.059.

Framingham Heart Study: JACC Focus Seminar, 1/8

Charlotte Andersson  1 , Matthew Nayor  2 , Connie W Tsao  3 , Daniel Levy  4 , Ramachandran S Vasan  5
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Free article
Review

Framingham Heart Study: JACC Focus Seminar, 1/8

Charlotte Andersson et al. J Am Coll Cardiol. .
Free article

Abstract

The Framingham Heart Study is the longest-running cardiovascular epidemiological study, starting in 1948. This paper gives an overview of the various cohorts, collected data, and most important research findings to date. In brief, the Framingham Heart Study, funded by the National Institutes of Health and managed by Boston University, spans 3 generations of well phenotyped White persons and 2 cohorts comprised of racial and ethnic minority groups. These cohorts are densely phenotyped, with extensive longitudinal follow-up, and they continue to provide us with important information on human cardiovascular and noncardiovascular physiology over the lifespan, as well as to identify major risk factors for cardiovascular disease. This paper also summarizes some of the more recent progress in molecular epidemiology and discusses the future of the study.

Keywords: Framingham Heart Study; cardiovascular epidemiology; molecular epidemiology; risk factors.

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Conflict of interest statement

Funding Support and Author Disclosures Dr. Nayor is supported by the National Heart, Lung, and Blood Institute (K23-HL138260). Dr. Tsao is supported by the National Institutes of Health (5R03-HL145195). Dr. Levy is supported by the Division of Intramural Research of the National Heart, Lung, and Blood Institute of the National Institutes of Health. Dr. Vasan is supported in part by the Evans Medical Foundation and the Jay and Louis Coffman Endowment from the Department of Medicine, Boston University School of Medicine. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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