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. 1978 Feb 10;253(3):765-9.

The RNA primer synthesized by primase to initiate phage G4 DNA replication

J P Bouché, L Rowen, A Kornberg
  • PMID: 340458
Free article

The RNA primer synthesized by primase to initiate phage G4 DNA replication

J P Bouché et al. J Biol Chem. .
Free article

Abstract

With phage G4 DNA as template, primase (the dnaG protein) synthesizes a 26- to 29-residue RNA transcript at the origin of replication. The sequence starts with ATP and contains a hairpin region of one A-U and seven G-C base pairs. Covalent linkage between the RNA and the newly synthesized complementary DNA chain indicates that the RNA transcript serves as a primer.

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