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. 2021 Feb 10;7(5):FSO683.
doi: 10.2144/fsoa-2020-0150.

Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus

Sophia A Ederaine  1 , Johanny Lopez Dominguez  1 , Jamison A Harvey  2 , Aaron R Mangold  2 , Curtiss B Cook  3 , Heidi Kosiorek  4 , Matthew Buras  5 , Kyle Coppola  6 , Nina J Karlin  7
Affiliations

Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus

Sophia A Ederaine et al. Future Sci OA. .

Abstract

Aim: This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control.

Materials & methods: Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007-2017). Overall survival and recurrence-free survival were estimated using the Kaplan-Meier method. Hemoglobin A1c (HbA1c) and glucose level during the year following cancer diagnosis were compared using mixed models.

Results: HbA1c decreased over time in DM patients (p = 0.04). The 5-year overall survival was 61% in DM patients, compared with 78% in patients without DM (p = 0.004).

Conclusion: The presence of co-existing DM adversely impacted survival in patients with SCC. SCC did not affect glycemic control.

Keywords: cancer; diabetes; endocrinology; glycemic control; outcomes research; squamous cell carcinoma.

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Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

Figures

Figure 1.
Figure 1.. Estimated mean hemoglobin A1c value during year after squamous cell carcinoma diagnosis in patients with diabetes mellitus.
Figure 2.
Figure 2.. Estimated mean glucose value during first year after squamous cell carcinoma diagnosis.
Figure 3.
Figure 3.. Overall survival and recurrence free survival.
KM: Kaplan-Meier; NE: Not estimated; OS: Overall survival; RFS: Recurrence-free survival.
See this image and copyright information in PMC

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