Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May 11:8:581311.
doi: 10.3389/fmed.2021.581311. eCollection 2021.

Metformin, the Rise of a New Medical Therapy for Endometriosis? A Systematic Review of the Literature

Emanuela Stochino-Loi  1 , Attila L Major  1   2 , Tessa E R Gillon  1 , Jean-Marc Ayoubi  3 , Anis Feki  1 , Jean Bouquet de Joliniere  1
Affiliations

Metformin, the Rise of a New Medical Therapy for Endometriosis? A Systematic Review of the Literature

Emanuela Stochino-Loi et al. Front Med (Lausanne). .

Abstract

Medical treatments for endometriosis aim to control pain symptoms and stop progression of endometriotic lesions. However, their adverse effects and their contraceptive effect in women who desire pregnancy, limit their long terms use. Although there is only one study investigating the effects of metformin on women with endometriosis, metformin seems to have a unique therapeutic potential. It may be a helpful anti-inflammatory and antiproliferative agent in the treatment of endometriosis. As such metformin may be more beneficial thanks to the lack of serious side effects.

Keywords: contraceptives; endometriosis; fertility; medical therapy; metformin.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Vercellini P, Vigano P, Somigliana E, Fedele L. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. (2014) 10:261–75. 10.1038/nrendo.2013.255 - DOI - PubMed
    1. Mathey MP, Bouquet de Jolinière J, Major A, Pugin F, Monnard E, Fiche M, et al. . Endometriotic mass after hysterectomy in a 61 year old post- menopausal woman: a case report and update. Front Surg. (2019) 6:14. 10.3389/fsurg.2019.00014 - DOI - PMC - PubMed
    1. Secosan C, Balulescu L, Brasoveanu S, Balint O, Pirtea P, Dorin G, et al. . Endometriosis in menopause—renewed attention on a controversial disease. Diagnostics (Basel). (2020) 10:134. 10.3390/diagnostics10030134 - DOI - PMC - PubMed
    1. Abdallah AA. Gastric wall endometriosis in a postmenopausal woman. Egypt J Radiol Nucl Med. (2016) 47:1783–6. 10.1016/j.ejrnm.2016.08.005 - DOI
    1. Asencio F, Ribeiro HA, Ribeiro PA, Malzoni M, Adamyan L, Ussia A, et al. . Symptomatic endometriosis developing several years after menopause in the absence of increased circulating estrogen concentrations: a systematic review and seven case reports. Gynecol. Surg. (2019) 3:16. 10.1186/s10397-019-1056-x - DOI

Publication types