Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;34(6):1549-1559.
doi: 10.1111/jar.12899. Epub 2021 May 28.

Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre- and post-bright light therapy: First explorations

Pauline C M Hamers  1   2 , Mesut Savas  3 , Elisabeth F C van Rossum  3 , Yolanda B de Rijke  4 , Patrick J E Bindels  5 , Dederieke A M Festen  1   6 , Heidi Hermans  1   2
Affiliations

Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre- and post-bright light therapy: First explorations

Pauline C M Hamers et al. J Appl Res Intellect Disabil. 2021 Nov.

Abstract

Background: Depressive symptoms and stress are common in adults with intellectual disabilities. Our aim was to explore long-term biological stress levels, assessed by hair cortisol (HairF) and cortisone (HairE) concentrations, in adults with intellectual disabilities and depressive symptoms and to investigate the effects of bright light therapy (BLT) on hair glucocorticoids.

Method: Scalp hair samples (n = 14) were retrospectively examined at baseline and post-BLT (10.000 and 300 lux). Liquid chromatography-tandem mass spectrometry was used to measure hair glucocorticoids.

Results: A significant correlation was found between baseline HairF and depression scores (r = .605, p = .028). Post-intervention HairE levels were significantly increased ([95% CI: 11.2-17.4 pg/mg], p = .003), in particular after dim light (300 lux) ([95% CI: 10.0-18.3 pg/mg], p = .020).

Conclusions: This study showed that retrospectively examining biological levels of stress in adults with intellectual disabilities seems a potentially promising and objective method to gain insight in the stress level of adults with intellectual disabilities.

Keywords: bright light therapy; cortisol; cortisone; depression; intellectual disabilities; long-term stress.

PubMed Disclaimer

Conflict of interest statement

All authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Flow diagram of data collection. *One participant was excluded from the analyses because of no compliance with the study protocol
See this image and copyright information in PMC

References

    1. Baudrand, R. , & Vaidya, A. (2015). Cortisol dysregulation in obesity‐related metabolic disorders. Current Opinion in Endocrinology, Diabetes, and Obesity, 22(3), 143–149. - PMC - PubMed
    1. Beauloye, V. , Dhondt, K. , Buysse, W. , Nyakasane, A. , Zech, F. , De Schepper, J. , Van Aken, S. , De Waele, K. , Craen, M. , Gies, I. , Francois, I. , Beckers, D. , Desloovere, A. , Francois, G. , & Cools, M. (2015). Evaluation of the hypothalamic‐pituitary‐adrenal axis and its relationship with central respiratory dysfunction in children with Prader‐Willi syndrome. Orphanet Journal of Rare Diseases, 10, 106. - PMC - PubMed
    1. Böhmer, M. N. , Valstar, M. J. , Aarts, M. P. J. , Bindels, P. J. E. , Oppewal, A. , Someren, E. J. W. , & Festen, D. A. M. (2021). Shedding light on light exposure in elderly with intellectual disabilities. Journal of Intellectual Disability Research, 65(4), 361–372. - PMC - PubMed
    1. Bond, L. , Carroll, R. , Mulryan, N. , O'Dwyer, M. , O'Connell, J. , Monaghan, R. , Sheerin, F. , McCallion, P. , & McCarron, M. (2019). The association of life events and mental ill health in older adults with intellectual disability: Results of the wave 3 Intellectual Disability Supplement to The Irish Longitudinal Study on Ageing. Journal of Intellectual Disability Research, 63(5), 454–465. 10.1111/jir.12595 - DOI - PubMed
    1. Boucher, P. , & Plusquellec, P. (2019). Acute stress assessment from excess cortisol secretion: Fundamentals and perspectives. Frontiers in Endocrinology, 10, 749. - PMC - PubMed

Substances