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. 2021:2321:155-159.
doi: 10.1007/978-1-0716-1488-4_13.

Scoring Sepsis Severity in Mice

Tina S Mele  1
Affiliations

Scoring Sepsis Severity in Mice

Tina S Mele. Methods Mol Biol. 2021.

Abstract

A reliable scoring system that predicts the development of sepsis, septic shock, and death enables comparison of disease severity and treatment outcomes in animal models of sepsis. Mice are used in the majority of preclinical sepsis studies. We describe a murine sepsis score that evaluates seven clinical variables in an experimental mouse model of polymicrobial sepsis.

Keywords: Mouse model of sepsis; Sepsis severity score.

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References

    1. Martin GS, Mannino DM, Eaton S et al (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348:1546–1554 - DOI
    1. Buras JA, Holzmann B, Sitkovsky M (2005) Animal models of sepsis: setting the stage. Nat Rev Drug Discov 4:854–865 - DOI
    1. Esmon CT (2004) Why do animal models (sometimes) fail to mimic human sepsis? Crit Care Med 32:S219–S222 - DOI
    1. Marshall JC, Reinhart K, International Sepsis F (2009) Biomarkers of sepsis. Crit Care Med 37:2290–2298 - DOI
    1. Shrum B, Anantha RV, Xu SX et al (2014) A robust scoring system to evaluate sepsis severity in an animal model. BMC Res Notes 7:233 - DOI

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