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Clinical Trial
. 2021 Sep 1;96(9):E334-E338.
doi: 10.1002/ajh.26253. Epub 2021 Jun 9.

Prognostic impact of KMT2A-AFF1-positivity in 926 BCR-ABL1-negative B-lineage acute lymphoblastic leukemia patients treated in GIMEMA clinical trials since 1996

Alfonso Piciocchi  1 , Monica Messina  1 , Loredana Elia  2 , Antonella Vitale  2 , Stefano Soddu  1 , Anna Maria Testi  2 , Sabina Chiaretti  2 , Marco Mancini  2 , Francesco Albano  3 , Antonio Spadano  4 , Mauro Krampera  5 , Massimiliano Bonifacio  5 , Roberto Cairoli  6 , Calogero Vetro  7 , Florinda Colella  1 , Felicetto Ferrara  8 , Giuseppe Cimino  9 , Renato Bassan  10 , Paola Fazi  1 , Marco Vignetti  1   2
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Free article
Clinical Trial

Prognostic impact of KMT2A-AFF1-positivity in 926 BCR-ABL1-negative B-lineage acute lymphoblastic leukemia patients treated in GIMEMA clinical trials since 1996

Alfonso Piciocchi et al. Am J Hematol. .
Free article
No abstract available

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References

REFERENCES

    1. Moorman AV. The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia. Blood Rev. 2012;26(3):123-135.
    1. Meyer C, Burmeister T, Gröger D, et al. The MLL recombinome of acute leukemias in 2017. Leukemia. 2018;32(2):273-284.
    1. Thomas M, Gessner A, Vornlocher HP, Hadwiger P, Greil J, Heidenreich O. Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells. Blood. 2005;106(10):3559-3566.
    1. Chiaretti S, Vitale A, Cazzaniga G, et al. Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age cohorts. Haematologica. 2013;98(11):1702-1710.
    1. Moorman AV, Harrison CJ, Buck GA, et al. Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/eastern cooperative oncology group (ECOG) 2993 trial. Blood. 2007;109:3189-3197.

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