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Review
. 2021 May 31;402(9):1087-1102.
doi: 10.1515/hsz-2021-0168. Print 2021 Aug 26.

Pathomechanisms in hepatic encephalopathy

Dieter Häussinger  1 , Markus Butz  2 , Alfons Schnitzler  2 , Boris Görg  1
Affiliations
Review

Pathomechanisms in hepatic encephalopathy

Dieter Häussinger et al. Biol Chem. .

Abstract

Hepatic encephalopathy (HE) is a frequent neuropsychiatric complication in patients with acute or chronic liver failure. Symptoms of HE in particular include disturbances of sensory and motor functions and cognition. HE is triggered by heterogeneous factors such as ammonia being a main toxin, benzodiazepines, proinflammatory cytokines and hyponatremia. HE in patients with liver cirrhosis is triggered by a low-grade cerebral edema and cerebral oxidative/nitrosative stress which bring about a number of functionally relevant alterations including posttranslational protein modifications, oxidation of RNA, gene expression changes and senescence. These alterations are suggested to impair astrocyte/neuronal functions and communication. On the system level, a global slowing of oscillatory brain activity and networks can be observed paralleling behavioral perceptual and motor impairments. Moreover, these changes are related to increased cerebral ammonia, alterations in neurometabolite and neurotransmitter concentrations and cortical excitability in HE patients.

Keywords: MR spectroscopy; astrocytes; neurophysiology; oscillatory activity; osmotic and oxidative stress; transcranial magnetic stimulation.

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