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Case Reports
. 2021 May 28;21(1):212.
doi: 10.1186/s12883-021-02245-1.

Graves' disease with anti-GQ1b antibody syndrome: a rare case report

Tao Liang #  1 , Zhiwei Zhou #  1 , Xiaolin Hu  2 , Zhong Luo  3
Affiliations
Case Reports

Graves' disease with anti-GQ1b antibody syndrome: a rare case report

Tao Liang et al. BMC Neurol. .

Abstract

Background: Graves' disease and anti-GQ1b antibody syndrome are both autoimmune diseases, and there have been few reports on whether there is a correlation between the two. In this study, we present the case of a woman who was diagnosed with Graves' disease and anti-GQ1b antibody syndrome in succession.

Case presentation: The chief complaints of this patient were limb weakness and blurred vision. Graves' disease was diagnosed by examination of thyroid function and thyroid autoantibodies, but the clinical symptoms were not relieved after antihyperthyroidism treatment. Finally, it was found that Graves' disease was complicated by anti-GQ1b antibody syndrome, and the symptoms were relieved after treatment with glucocorticoids and intravenous immunoglobulin. We also explored the possible mechanism of these diseases through a literature review.

Conclusions: We report a rare case of the cooccurrence of Graves' disease and anti-GQ1b antibody syndrome. Immune dysregulation might be the pathogenesis of the association, but there is no precise supporting evidence, and more research is needed.

Keywords: Extraocular paralysis, case report; GQ1b antibody; Graves’ disease; Limb weakness.

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Conflict of interest statement

The authors declare that they have no commercial or financial conflicts of interest.

Figures

Fig. 1
Fig. 1
the patient’s MRI of the brain showed no damage of extraocular muscle. (A, B) T2WI axial image. (C, D) T1WI axial image
See this image and copyright information in PMC

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