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. 2021 Nov;41(11):2597-2606.
doi: 10.1038/s41372-021-01092-9. Epub 2021 May 28.

Association of timing of birth with mortality among preterm infants born in Canada

Angelo Rizzolo  1 , Prakesh S Shah  2 , Valerie Bertelle  3 , Hala Makary  4 , Xiang Y Ye  5 , Haim A Abenhaim  6 , Bruno Piedboeuf  7 , Marc Beltempo  8 ; Canadian Neonatal Network (CNN) and Canadian Preterm Birth Network (CPTBN) Investigators
Collaborators, Affiliations

Association of timing of birth with mortality among preterm infants born in Canada

Angelo Rizzolo et al. J Perinatol. 2021 Nov.

Abstract

Objective: To assess the association between time of birth and mortality among preterm infants.

Study design: Population-based study of infants born 22-36 weeks gestation (GA) in Canada from 2010 to 2015 (n = 173 789). Multivariable logistic regression models assessed associations between timing of birth and mortality.

Result: Among infants 22-27 weeks GA, evening birth was associated with higher mortality than daytime birth (adjusted odds ratio [AOR] 1.14, 95% CI 1.01-1.29). Among infants 28-32 weeks GA and 33-36 weeks GA, night birth was associated with lower mortality than daytime birth (AOR 0.75, 95% CI 0.59-0.95; AOR 0.78, 95% CI 0.62-0.99, respectively). Sensitivity analysis excluding infants with major congenital anomaly revealed that associations between hour of birth and mortality among infants born 28-32 and 33-36 weeks GA decreased or were not statistically significant.

Conclusion: Higher mortality among extremely preterm infants during off-peak hours may suggest variations in available resources based on time of day.

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References

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