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Review
. 2022 Mar;25(1):11-26.
doi: 10.1038/s41391-021-00394-5. Epub 2021 May 28.

Advances in PSMA-targeted therapy for prostate cancer

Fujin Wang  1   2 , Zhifeng Li  1 , Xiaoqian Feng  1   2 , Dazhuang Yang  1 , Mei Lin  3
Affiliations
Review

Advances in PSMA-targeted therapy for prostate cancer

Fujin Wang et al. Prostate Cancer Prostatic Dis. 2022 Mar.

Erratum in

Abstract

Prostate-specific membrane antigen (PSMA), a transmembrane glycoprotein located on the cell membrane, is specifically and highly expressed in prostate cancer (PCa). Besides, its expression level is related to tumor invasiveness. As a molecular target of PCa, PSMA has been extensively studied in the past two decades. Currently, a great deal of evidence suggests that significant progresses have been made in the PSMA-targeted therapy of PCa. Herein, different PSMA-targeted therapies for PCa are reviewed, including radioligand therapy (177Lu-PSMA-RLT, 225Ac-PSMA-RLT), antibody-drug conjugates (MLN2704, PSMA-MMAE, MEDI3726), cellular immunotherapy (CAR-T, CAR/NK-92, PSMA-targeted BiTE), photodynamic therapy, imaging-guided surgery (radionuclide-guided surgery, fluorescence-guided surgery, multimodal imaging-guided surgery), and ultrasound-mediated nanobubble destruction.

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