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Review
. 2022 Jun;37(6):1231-1243.
doi: 10.1007/s00467-021-05126-4. Epub 2021 May 29.

Sickle cell nephropathy: insights into the pediatric population

Oyindamola C Adebayo  1   2 , Lambertus P Van den Heuvel  1   3 , Wasiu A Olowu  4 , Elena N Levtchenko  5   6 , Veerle Labarque  2   7
Affiliations
Review

Sickle cell nephropathy: insights into the pediatric population

Oyindamola C Adebayo et al. Pediatr Nephrol. 2022 Jun.

Abstract

The life expectancy of individuals with sickle cell disease has increased over the years, majorly due to an overall improvement in diagnosis and medical care. Nevertheless, this improved longevity has resulted in an increased prevalence of chronic complications such as sickle cell nephropathy (SCN), which poses a challenge to the medical care of the patient, shortening the lifespan of patients by 20-30 years. Clinical presentation of SCN is age-dependent, with kidney dysfunction slowly beginning to develop from childhood, progressing to chronic kidney disease and kidney failure during the third and fourth decades of life. This review explores the epidemiology, pathology, pathophysiology, clinical presentation, and management of SCN by focusing on the pediatric population. It also discusses the factors that can modify SCN susceptibility.

Keywords: Children; Kidney disease; Sickle cell disease; Sickle cell nephropathy.

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