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Review
. 2021:59:51-97.
doi: 10.1007/978-3-030-67696-4_4.

Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry

Wen-An Wang  1 , Nicolas Demaurex  2
Affiliations
Review

Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry

Wen-An Wang et al. Prog Mol Subcell Biol. 2021.

Abstract

The endoplasmic reticulum (ER) Ca2+ sensor stromal interaction molecule 1 (STIM1) interacts with ORAI Ca2+ channels at the plasma membrane to regulate immune and muscle cell function. The conformational changes underlying STIM1 activation, translocation, and ORAI1 trapping and gating, are stringently regulated by post-translational modifications and accessory proteins. Here, we review the recent progress in the identification and characterization of ER and cytosolic proteins interacting with STIM1 to control its activation and deactivation during store-operated Ca2+ entry (SOCE).

Keywords: Cell signaling; Endoplasmic reticulum; Immunity; Ion channels; Protein trafficking.

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References

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