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Observational Study
. 2021 Aug;83(2):237-279.
doi: 10.1016/j.jinf.2021.05.023. Epub 2021 May 27.

One-year durability of anti-spike IgG to SARS-CoV-2: Preliminary data from the anticrown prospective observational study one year durability of COVID-19 anti-spike IgG

Amedeo F Capetti  1 , Fabio Borgonovo  2 , Davide Mileto  3 , Gloria Gagliardi  3 , Chiara Mariani  4 , Angelica Lupo  2 , Gianfranco Dedivitiis  2 , Paola Meraviglia  2 , Martina Pellicciotta  2 , Luciana Armiento  2 , Maria V Cossu  2 , Giuliano Rizzardini  2
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Observational Study

One-year durability of anti-spike IgG to SARS-CoV-2: Preliminary data from the anticrown prospective observational study one year durability of COVID-19 anti-spike IgG

Amedeo F Capetti et al. J Infect. 2021 Aug.

Abstract

Data are presented of 368/503 post-COVID-19 outpatients followed within the AntiCROWN Cohort who have a one-year control and a baseline assessment of anti-S1/S2 antibodies, detected with the The LIAISON® SARS-CoV-2 S1/S2 IgG solution by DiaSorin. Loss of response occurred in 4 subjects having a baseline level below 50 AU/mL.

Keywords: Antibodies; COVID-19; Coronavirus; Durability; Observational; Spike.

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Fig 1
Fig. 1
One Year follow-up of anti-S1/S2 antibody levels in subjects: A, with baselibe lavels <15 AU/mL; B, with baseline levels 15 to 50 AU/mL; C, with baseline levels >50 AU/mL. D: responses in vaccinated subjects (Results limited by ceiling cut-off effect at 400 AU/mL)).
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References

    1. Harris RJ, Whitaker HJ, Andrews NJ. Serological surveillance of SARS-CoV-2: six-month trends and antibody response in a cohort of public health workers. J Infect. 2021;82(5):162–169. doi: 10.1016/j.jinf.2021.03.015. May. - DOI - PMC - PubMed
    1. DiaSorin. LIAISON Ⓡ SARS-CoV-2 S1/S2 IgG the fully automated serology test for the detection of SARS CoV-2 IgG antibodies. https://www.diasorin.com/sites/default/files/allegati/liaisonr_sars-cov2... (accessed on 12 May, 2021).
    1. World Health Organization. Clinical management of COVID-19. https://www.who.int/publications/i/item/clinical-management-of64covid-19 (accessed on 12 May, 2021).
    1. Lumley SF, O'Donnell D, Stoesser NE, the Oxford University Hospitals Staff Testing Group Antibody status and incidence of SARS-CoV-2 infection in health care workers. N Engl J Med. 2021;384(6):533–540. doi: 10.1056/NEJMoa2034545. - DOI - PMC - PubMed
    1. Capetti AF, Stangalini CA, Borgonovo F. Impressive boosting of anti-S1/S2 IgG production in COVID-19-experienced patients after the first shot of the BNT162b2 mRNA COVID-19 Vaccine. Clin Infect Dis. 2021 Mar 6 doi: 10.1093/cid/ciab214. ciab214Epub 2021 Feb. 3. - DOI - PMC - PubMed