Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2021 Dec;34(6):903-914.
doi: 10.1007/s10334-021-00933-0. Epub 2021 May 29.

Quantitative comparison of subcortical and ventricular volumetry derived from MPRAGE and MP2RAGE images using different brain morphometry software

Juli Alonso  1   2   3 , Deborah Pareto  4   5   6 , Manel Alberich  4   5 , Tobias Kober  7   8   9 , Bénédicte Maréchal  7   8   9 , Xavier Lladó  10 , Alex Rovira  4   5   6
Affiliations
Comparative Study

Quantitative comparison of subcortical and ventricular volumetry derived from MPRAGE and MP2RAGE images using different brain morphometry software

Juli Alonso et al. MAGMA. 2021 Dec.

Abstract

Objective: In brain volume assessment with MR imaging, it is of interest to know the effects of the pulse sequence and software used, to determine whether they provide equivalent data. The aim of this study was to compare cross-sectional volumes of subcortical and ventricular structures and their repeatability derived from MP2RAGE and MPRAGE images using MorphoBox, and FIRST or ALVIN.

Materials and methods: MPRAGE and MP2RAGE T1-weighted images were obtained from 24 healthy volunteers. Back-to-back scans were performed in 12 of them. Volumes, coefficients of variation, concordance, and correlations were determined.

Results: Significant differences were found for volumes derived from MorphoBox and FIRST. Ventricular volumes determined by MorphoBox and ALVIN were similar. Differences between volumes obtained using MPRAGE and MP2RAGE were significant for a few regions. Coefficients of variation, ranged from 0.2 to 9.1%, showed a significant inverse correlation with the mean volume. There was a correlation between volume measures, but agreement was rated as poor for most regions.

Conclusion: MP2RAGE sequences and MorphoBox are valid options for assessing subcortical and ventricular volumes, in the same way as MPRAGE and FIRST or ALVIN, accepted tools for clinical research. However, caution is needed when comparing volumes obtained with different tools.

Keywords: Lateral ventricle; MP2RAGE; MPRAGE; Magnetic resonance imaging; Subcortical structures.

PubMed Disclaimer

References

    1. Hedderich DM, Dieckmeyer M, Andrisan T, Ortner M, Grundl L, Schon S et al (2020) Normative brain volume reports may improve differential diagnosis of dementing neurodegenerative diseases in clinical practice. Eur Radiol 30:2821–2829 - DOI
    1. Bisenius S, Neumann J, Schroeter ML (2016) Validating new diagnostic imaging criteria for primary progressive aphasia via anatomical likelihood estimation meta-analyses. Eur J Neurol 23:704–712 - DOI
    1. Gonzalez-Villa S, Oliver A, Valverde S, Wang LP, Zwiggelaar R, Llado X (2016) A review on brain structures segmentation in magnetic resonance imaging. Artif Intell Med 73:45–69 - DOI
    1. Giorgio A, De Stefano N (2013) Clinical use of brain volumetry. J Magn Reson Imaging 37:1–14 - DOI
    1. Morey RA, Petty CM, Xu Y, Hayes JP, Wagner HR, Lewis DV et al (2009) A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes. Neuroimage 45:855–866 - DOI

Publication types

LinkOut - more resources