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. 2021 May;25(Suppl 1):S3-7.
doi: 10.5213/inj.2142174.087. Epub 2021 May 31.

Irreversible Bladder Remodeling Induced by Fibrosis

Su Jin Kim  1 , Jayoung Kim  2   3   4   5 , Yong Gil Na  6 , Khae Hawn Kim  6
Affiliations

Irreversible Bladder Remodeling Induced by Fibrosis

Su Jin Kim et al. Int Neurourol J. 2021 May.

Abstract

Underactive bladder and impaired bladder compliance are irreversible problems associated with bladder fibrosis. Remodeling of the extracellular matrix is regarded as an important mechanism associated with bladder fibrosis. However, various risk factors and conditions contribute to the functional impairment of the bladder associated with fibrosis, and there is limited knowledge about bladder fibrosis-associated problems in the field of neurourology. Further studies are thus necessary to elucidate the underlying mechanism of bladder fibrosis and to identify effective treatment.

Keywords: Collagen; Extracellular matrix; Fibrosis; Lower urinary tract symptoms; Urinary bladder.

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Conflict of interest statement

Conflict of Interest

SJK and KHK, associate editors of International Neurourology Journal, are the authors of this article. However, they played no role whatsoever in the editorial evaluation of this article or the decision to publish it. Except for that, no potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Potential theoretical mechanism of bladder fibrosis-associated voiding problems. ECM, extracelluar matrix; TGF-β1, transforming growth factor-β1; UAB, underactive bladder.
See this image and copyright information in PMC

Comment in

References

    1. Barnard RJ, Dixon JS, Gosling JA. A clinical and morphological evaluation of the trabeculated urinary bladder. Prog Clin Biol Res. 1981;78:285–8. - PubMed
    1. Jung JH, Cho SY, Yoo C, Oh SJ. Establishment of the novel cystoscopic classification for bladder trabeculation of neurogenic bladder. Urology. 2014;84:515–9. - PubMed
    1. Selby B, Hidas G, Chuang KW, Soltani T, Billimek J, Kaplan S, et al. Development and validation of a bladder trabeculation grading system in pediatric neurogenic bladder. J Pediatr Urol. 2020;16:367–70. - PubMed
    1. Hoffberg HJ, Cardenas DD. Bladder trabeculation in spinal cord injury. Arch Phys Med Rehabil. 1986;67:750–3. - PubMed
    1. Bai SW, Park SH, Chung DJ, Park JH, Shin JS, Kim SK, et al. The significance of bladder trabeculation in the female lower urinary system: an objective evaluation by urodynamic studies. Yonsei Med J. 2005;46:673–8. - PMC - PubMed