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Meta-Analysis
. 2021 Jan-Dec:17:17455065211019717.
doi: 10.1177/17455065211019717.

A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project

Gayathri Delanerolle  1 , Rema Ramakrishnan  2 , Dharani Hapangama  3   4 , Yutian Zeng  5 , Ashish Shetty  6   7 , Sohier Elneil  6   7 , Sam Chong  6   7 , Martin Hirsch  6   8 , Molola Oyewole  6   7 , Peter Phiri  9   10 , Kathryn Elliot  9 , Trusha Kothari  4 , Bryony Rogers  3   4 , Natasha Sandle  1 , Nyla Haque  1 , Nicola Pluchino  11 , Martin Silem  12 , Rebecca O'Hara  13 , M Louise Hull  13 , Kingshuk Majumder  14 , Jian Qing Shi  5   15 , Vanessa Raymont  1   16
Affiliations
Meta-Analysis

A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project

Gayathri Delanerolle et al. Womens Health (Lond). 2021 Jan-Dec.

Abstract

Background: It is important to evaluate sequalae for complex chronic health conditions such as endometriosis and mental health disorders. Endometriosis impacts 1 in 10 women. Mental health outcomes can be a primary determinant in many physical health conditions although this is an area not well researched particularly in women's health. This has been problematic for endometriosis patients in particular, who report mental health issues as well as other key comorbidities such as chronic pelvic pain and infertility. This could be partly due to the complexities associated with comprehensively exploring overlaps between physical and mental health disorders in the presence of multiple comorbidities and their potential mechanistic relationship.

Methods: In this evidence synthesis, a systematic methodology and mixed-methods approaches were used to synthesize both qualitative and quantitative data to examine the prevalence of the overlapping sequalae between endometriosis and psychiatric symptoms and disorders. As part of this, an evidence synthesis protocol was developed which included a systematic review protocol that was published on PROSPERO (CRD42020181495). The aim was to identify and evaluate mental health reported outcomes and prevalence of symptoms and psychiatric disorders associated with endometriosis.

Findings: A total of 34 papers were included in the systematic review and 15 were included in the meta-analysis. Anxiety and depression symptoms were the most commonly reported mental health outcomes while a pooled analysis also revealed high prevalence of chronic pelvic pain and dyspareunia.

Interpretation: It is evident that small-scale cross-sectional studies have been conducted in a variety of settings to determine mental health outcomes among endometriosis patients. Further research is required to comprehensively evaluate the mental health sequalae with endometriosis.

Keywords: BAME; adenomyosis; chronic pelvic pain; dysmenorrhea; dyspareunia; endometriosis; mental health; women’s health; women’s mental health.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
PRISMA chart.
Figure 2.
Figure 2.
Forest plot of pooled prevalence of (a) anxiety among women with endometriosis, (b) depression among women with endometriosis.
Figure 3.
Figure 3.
Forest plot of prevalence odds ratio of (a) anxiety among women with endometriosis compared to women without endometriosis, (b) depression among women with endometriosis compared to women without endometriosis.
Figure 4.
Figure 4.
Forest plot of pooled prevalence of (a) chronic pelvic pain among women with endometriosis, (b) dyspareunia among women with endometriosis.
See this image and copyright information in PMC

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