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Comment
. 2021 Aug;44(8):602-604.
doi: 10.1016/j.tins.2021.05.001. Epub 2021 May 27.

Membrane molecules for mood

David A Slattery  1 , John F Cryan  2
Affiliations
Comment

Membrane molecules for mood

David A Slattery et al. Trends Neurosci. 2021 Aug.

Abstract

According to the decades-old neurotrophic hypothesis of depression, the delayed actions of antidepressants are purported to be due to their downstream effects on neuronal plasticity. In a recent study, Casarotto et al. reveal that antidepressants can in fact directly bind to the neurotrophin TRKB receptor and exert their effects through this mechanism.

Keywords: BDNF; antidepressant; depression; plasticity.

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Conflict of interest statement

Declaration of interests J.F.C. is a member of the Advisory Board of Trends in Neurosciences. The authors declare no other competing interests in relation to this work.

Comment on

  • Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
    Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrén E. Casarotto PC, et al. Cell. 2021 Mar 4;184(5):1299-1313.e19. doi: 10.1016/j.cell.2021.01.034. Epub 2021 Feb 18. Cell. 2021. PMID: 33606976 Free PMC article.

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