Iatrogenic Toxicities in the Intensive Care Unit

Abstract

Drug-induced iatrogenic toxicities are common in critically ill patients and have been associated with increased morbidity and mortality. Early recognition and management of iatrogenic toxicities is essential; however, the diagnosis is usually complicated by the underlying critical illness, comorbidities, and administration of multiple medications. This article reviews several types of iatrogenic toxicities associated with medications that are commonly used in critically ill patients. The mechanism of the iatrogenic toxicities, clinical presentation, and diagnosis, as well as management are discussed.

Keywords: Adverse drug reactions; Critical illness; Drug-related side effects and adverse reactions; Iatrogenic disease; Intensive care units.