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. 2021 Mar 31;34(1):3-9.

Inflammatory and coagulative pathophysiology for the management of burn patients with COVID-19: systematic review of the evidence

S Al-Benna  1
Affiliations

Inflammatory and coagulative pathophysiology for the management of burn patients with COVID-19: systematic review of the evidence

S Al-Benna. Ann Burns Fire Disasters. .

Abstract
in English, French

The pathogenesis of coronavirus disease 2019 (COVID-19) involves a prominent innate immune response to SARS-CoV-2 infection, including inflammatory cytokines, chemokines, the complement system and acute phase proteins. This hyperinflammatory response predisposes patients to thromboembolic disease, acute lung injury, acute respiratory distress syndrome and multiple organ dysfunction syndrome. In burn injuries, damaged tissues induce a local and systemic inflammatory response through pathways associated to COVID-19. As such, a COVID-19 positive patient sustaining burn injuries may have an amplified response to the burn insult due to their baseline hyperinflammatory and hypercoagulable states. Burn patients may have compromised physiological reserve to withstand the insult of surgical intervention before reaching clinical instability. The concurrent pathogenesis of COVID-19 and the inflammatory response in burn injury have serious implications on the management of burn patients.

L’infection par COVID- 19 peut entraîner une réponse explosive du système immunitaire avec sécrétion/activation de cytokines, chémokines, complément et protéines de l’inflammation. Cette réponse inflammatoire rend le patient à risque de phénomènes thrombo- emboliques, de lésions respiratoire pouvant conduire à un SDRA et de défaillance multiviscérale. Cette cascade est proche de celle observée en cas de brûlure étendue si bien que les patients brûlés- COVID19 pourraient avoir une réponse immunitaire encore plus intense et n’avoir plus aucune « réserve de défense » quand il faudra les opérer. La concomitance brûlure- COVID19 peut ainsi avoir des implications majeures quant à la prise en charge de la brûlure.

Keywords: COVID-19; acute phase proteins; blood coagulation disorders; burn; chemokines; complement system proteins; coronavirus; cytokines; severe acute respiratory syndrome coronavirus 2.

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Figures

Table I
Table I. Considerations for COVID-19 positive patients with burn injuries
See this image and copyright information in PMC

References

    1. Al-Benna S. Pathophysiology of coronavirus disease 2019 for wound care professionalsX. Int Wound J. 2020;17:1935–1940. - PMC - PubMed
    1. Al-Benna S, Gohritz A. Availability of COVID-19 information from national and international burn society websites. Ann Burns Fire Disasters. 2020;33:177–181. - PMC - PubMed
    1. Al-Benna S, Gohritz A. Availability of COVID-19 information from national plastic surgery society websites. Ann Plast Surg. 2020;85:S171–S171. - PMC - PubMed
    1. Al-Benna S. Availability of COVID-19 information from national and international aesthetic surgery society websites. Aesthetic Plast Surg. 2020;44:1043–1046. - PMC - PubMed
    1. Worldometer: COVID-19 Coronavirus Pandemic. [27th August 2020]; Available from: https://www.worldometers.info/coronavirus/ .

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