Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 31;34(1):26-32.

Influence Of Pre-Existing Neurological Illnesses On The Outcome Of Severe Burn Injuries

M Daniels  1 , M Becker  1 , R Lefering  2 , P C Fuchs  1 , E Demir  1 , A Schulz  1 , W Perbix  1 , D Grigutsch  3 , J L Schiefer  1
Affiliations

Influence Of Pre-Existing Neurological Illnesses On The Outcome Of Severe Burn Injuries

M Daniels et al. Ann Burns Fire Disasters. .

Abstract
in English, French

It is known that patients suffering from neurological illnesses have an increased risk of burn injuries. These burns are often very severe and lead to poor outcomes. To date, only a few studies have evaluated the impact of pre-existing neurological illnesses on the outcome of burn injuries. None of them performed a regression analysis regarding specific influence on mortality. Between 1996 and 2016, 1475 patients were admitted to the BICU of a specialized German burn center: 26 had less than 1% TBSA burned and were excluded; 177 had pre-existing neurological disorders (group N). 87 patients with psychological disorders were excluded. 1185 patients without neurological or psychological disorders formed the control group. Length of hospital stay, TBSA and number of operations were analyzed using the chi-squared test and Mann-Whitney U-test. Additionally, mortality was evaluated using the logistic regression analysis adjusted for known outcome predictors. Mean age of the patients in the control group was 41.53 years with a BICU stay of 18 days, TBSA of 18.25% and mortality rate of 12.4%; 23.7% had inhalation injuries. Patients in group N had a mean age of 54.63 years, a BICU stay of 27 days, mean TBSA of 20.97%; 31.1% had inhalation injuries and mortality was 20.3%. Patients with neurological disorders were older and showed higher affected TBSA, higher rates of inhalation injury, mortality and affected TBSA, and a longer stay in the BICU compared to the control group. Nevertheless, pre-existing neurological disorders alone had no significant influence on mortality.

Il est avéré que les patients souffrant de pathologie neurologique ont un risque plus élevé de brûlure. Elles sont souvent particulièrement graves et d’évolution défavorable mais la littérature à ce sujet reste pauvre et aucune étude n’a utilisé de régression logistique pour évaluer la corrélation pathologie neurologique- évolution d’une brûlure. Entre 1996 et 2016, 1 475 patients ont été hospitalisés en réanimation spécifique dans un CTB allemand. Vingt- six d’entre eux, brûlés sur moins de 1% SCT, n’ont pas été inclus dans l’étude, pas plus 87 patients psychiatriques si bien que 177 patients souffrant de pathologie neurologique (N) ont été comparés à 1 185 n’en souffrant pas (C). Les durées d’hospitalisation, la surface brûlée et le nombre d’interventions chirurgicales ont été analysée en utilisant C² ou Mann-Whitney. En outre, nous avons effectué une régression logistique étudiant la mortalité, en utilisant les facteurs connus de mortalité. Le groupe C avait 41,53 ans, souffrait de brûlures sur 18,25% SCT, avait inhalé des fumées dans 23,7% des cas, avait un taux de mortalité de 12,4% et restait 18 j en réanimation. Dans le groupe N, ces chiffres étaient respectivement de 54,63 ans, 20,97% SCT, 31,1% de fumées, 20,3% de mortalité et 27 jours en réa. Tous les chiffres étudiés étaient plus élevés dans N que dans C. Toutefois, l’existence de comorbidité neurologique n’apparaissait pas un critère indépendant de mortalité.

Keywords: BICU; burn injuries; burn mortality; neurological disorders.

PubMed Disclaimer

Figures

Table I
Table I. Overview of included neurological diseases
Table II
Table II. Overview of included patients, sex, age, TBSA, number of operations, days of hospital and BICU stay and mortality
Fig. 1
Fig. 1. Overview of mortality, inhalation injury and mean TBSA in % of the two groups in direct comparison
Table III
Table III. Multi-variant analysis regarding the influence on mortality; pre-existing neurological illnesses had no significant influence in mortality (p<0.05)
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Harvey L, Mitchell R, Brodaty H, Draper B, Close J. Dementia: a risk factor for burns in the elderly. Burns. 2016;42(2):282–290. - PubMed
    1. Knowlin L, Stanford L, Moore D, Cairns B, Charles A. The measured effect magnitude of co-morbidities on burn injury mortality. Burns. 2016;42(7):1433–1438. - PMC - PubMed
    1. Backstein R, Peters W, Neligan P. Burns in the disabled. Burns. 1993;43(5):192–197. - PubMed
    1. Hudson A, Al Youha S, Samargandi OA, Paletz J. Pre-existing psychiatric disorder in the burn patient is associated with worse outcomes. Burns. 2017;43(5):973–982. - PubMed
    1. Benjamin C, Gittler M, Lee R. Burn from car seat heater in a man with paraplegia: case report. J Spinal Cord Med. 2011;34(3):332–334. - PMC - PubMed

LinkOut - more resources