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Case Reports
. 2021 May 14:12:598661.
doi: 10.3389/fphar.2021.598661. eCollection 2021.

Case Report: Spontaneous Intramural Hematoma of the Colon Secondary to Low Molecular Weight Heparin Therapy

Ye Zhu  1 , Chao Wang  1 , Chao Xu  2 , Jia Liu  1
Affiliations
Case Reports

Case Report: Spontaneous Intramural Hematoma of the Colon Secondary to Low Molecular Weight Heparin Therapy

Ye Zhu et al. Front Pharmacol. .

Abstract

Background: Hematoma of the colon is a rare hemorrhagic complication that affects patients accepting low molecular weight heparin (LMWH) therapy. Only scarce cases of colon hematoma have been reported, usually in children or patients accepting warfarin therapy. Case summary: A 76-year-old Chinese man was diagnosed with atrial fibrillation and heart failure, with cardiac function NYHA grade III on March 21, 2018. This patient was given LMWH for anticoagulation therapy and developed a colon hematoma on the third day of hospitalization. Abdominal computed tomography (CT) showed the thickening of areas of the colon up to 110 mm × 78 mm in thickness, which was a symptom of colon hematoma. The patient underwent conservative treatment successfully. On March 27, the patient's abdominal pain was alleviated, and a CT scan showed that the intestinal hematoma was absorbed. Conclusions: The most frequent minor bleeding events of LMWH anticoagulation are hemorrhage and subcutaneous hematoma. This case demonstrated that bowel hematoma despite its low incidence should be considered as an ADR of LMWH therapy, especially among patients who present with gastrointestinal symptoms.

Keywords: anticoagulation; bowel; case report; hematoma; low molecular weight heparin.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE1
FIGURE1
Abdominal computed tomography images. (A, B) Contrast-enhanced computed tomography (CT) images showing a hematoma of the colon (arrows) on March 23, 2018; C: CT image revealed that the colon hematoma had been absorbed (arrow) on March 27, 2018.
See this image and copyright information in PMC

References

    1. Bettler S., Montani S., Bachmann F. (1983). [Incidence of Intramural Digestive System Hematoma in Anticoagulation. Epidemiologic Study and Clinical Aspects of 59 Cases Observed in Switzerland (1970–1975)]. Schweiz Med. Wochenschr 113 (17), 630–636. - PubMed
    1. Choi B. H., Koeckert M., Tomita S. (2018). Intramural Bowel Hematoma Presenting as Small Bowel Obstruction in a Patient on Low-Molecular-Weight Heparin. Case Rep. Pediatr. 2018, 1–3. 10.1155/2018/8780121 - DOI - PMC - PubMed
    1. Chung K. T. (2016). Intra-Abdominal Hematoma Following Enoxaparin Injection. Clin. Med. Insights Case Rep. 9, 1–38. 10.4137/CCRep.S17881 - DOI - PMC - PubMed
    1. Hao C., Sun M., Wang H., Zhang L., Wang W. (2019). Low Molecular Weight Heparins and Their Clinical Applications. Prog. Mol. Biol. Transl. Sci. 163, 21–39. 10.1016/bs.pmbts.2019.02.003 - DOI - PubMed
    1. Levine M. N., Raskob G., Beyth R. J., Kearon C., Schulman S. (2004). Hemorrhagic Complications of Anticoagulant Treatment. Chest 126 (3 Suppl. l), 287s–310s. 10.1378/chest.126.3_suppl.287S - DOI - PubMed

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