The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity

doi:10.1155/2021/5510552

. 2021 May 7:2021:5510552.

doi: 10.1155/2021/5510552. eCollection 2021.

The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity

Hsiang-I Hou¹, Hsing-Yu Chen^{1

2

3}, Jang-Jih Lu^{4

5

6}, Shih-Cheng Chang^{4

5}, Hsueh-Yu Li^{7

8}, Kun-Hao Jiang^{1

3}, Jiun-Liang Chen^{1

3}

Affiliations

¹ Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
² Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
³ School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁴ Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
⁵ Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁶ Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁷ Department of Otolaryngology, Chang Gung Memorial Hospital, Gueishan County, Taoyuan, Taiwan.
⁸ Department of Otolaryngology-Head and Neck Surgery, Sleep Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

PMID: 34055005
PMCID: PMC8123988
DOI: 10.1155/2021/5510552

The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity

Hsiang-I Hou et al. Evid Based Complement Alternat Med. 2021.

. 2021 May 7:2021:5510552.

doi: 10.1155/2021/5510552. eCollection 2021.

Authors

Hsiang-I Hou¹, Hsing-Yu Chen^{1

2

3}, Jang-Jih Lu^{4

5

6}, Shih-Cheng Chang^{4

5}, Hsueh-Yu Li^{7

8}, Kun-Hao Jiang^{1

3}, Jiun-Liang Chen^{1

3}

Affiliations

¹ Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
² Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
³ School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁴ Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
⁵ Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁶ Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁷ Department of Otolaryngology, Chang Gung Memorial Hospital, Gueishan County, Taoyuan, Taiwan.
⁸ Department of Otolaryngology-Head and Neck Surgery, Sleep Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

PMID: 34055005
PMCID: PMC8123988
DOI: 10.1155/2021/5510552

Abstract

Methods: The adults with body mass index (BMI) more than 27 kg/m² were enrolled in the study. General personal information, physical condition, TCMBC, biochemical, and SNPs were collected for eligible subjects. The body constitution questionnaire (BCQ) was used to evaluate the relationships between TCMBC tendency, biochemical values, and obesity-related SNPs.

Results: Obesity patients tended to have a yin deficiency constitution (YinDC) (n = 33, 66.0%); however, TCMBC in combination is not uncommon (30 subjects with more than two TCMBC in combination). For biochemical profiles, leptin was higher among patients with yang deficiency constitution (YangDC) (YangDC versus non-YangDC: 29.7 ± 24.8 versus 15.9 ± 9.9, P=0.020) and YinDC (YinDC versus non-YinDC: 28.8 ± 23.5 versus 14.4 ± 9.6, P=0.020). The leptin level was highest among YangDC subjects. Higher leptin was found among subjects with three-combined TCMBC than balanced TCMBC subjects who were not inclined to any of three TCMBC. For obesity-related SNPs, the adrenergic receptor beta-3 (ADRB3) gene tended to be high expression among YangDC (YangDC versus non-YangDC: 89.7% versus 71.4%, P=0.091) and uncoupling protein 1 (UCP1) tended to be high expression among phlegm-stasis constitution (PSC) (PSC versus non-PSC: 37.9% versus 9.5%, P=0.052).

Conclusions: The relationships between TCMBC, leptin, and SNPs present alternative viewpoints about TCMBC and could be used as a guide to treat obese patients.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

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[1] Hu F. B. Obesity and mortality: watch your waist, not just your weight. Archives of Internal Medicine. 2007;167(9):875–876. doi: 10.1001/archinte.167.9.875. - DOI - PubMed

[2] Hu F. B. Obesity and mortality: watch your waist, not just your weight. Archives of Internal Medicine. 2007;167(9):875–876. doi: 10.1001/archinte.167.9.875. - DOI - PubMed

[3] Finucane M. M., Stevens G. A., Cowan M. J., et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. The Lancet. 2011;377(9765):557–567. doi: 10.1016/s0140-6736(10)62037-5. - DOI - PMC - PubMed

[4] Finucane M. M., Stevens G. A., Cowan M. J., et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. The Lancet. 2011;377(9765):557–567. doi: 10.1016/s0140-6736(10)62037-5. - DOI - PMC - PubMed

[5] Finkelstein E. A., Khavjou O. A., Thompson H., et al. Obesity and severe obesity forecasts through 2030. American Journal of Preventive Medicine. 2012;42(6):563–570. doi: 10.1016/j.amepre.2011.10.026. - DOI - PubMed

[6] Finkelstein E. A., Khavjou O. A., Thompson H., et al. Obesity and severe obesity forecasts through 2030. American Journal of Preventive Medicine. 2012;42(6):563–570. doi: 10.1016/j.amepre.2011.10.026. - DOI - PubMed

[7] Hwang L.-C., Bai C.-H., Chen C.-J. Prevalence of obesity and metabolic syndrome in Taiwan. Journal of the Formosan Medical Association. 2006;105(8):626–635. doi: 10.1016/s0929-6646(09)60161-3. - DOI - PubMed

[8] Hwang L.-C., Bai C.-H., Chen C.-J. Prevalence of obesity and metabolic syndrome in Taiwan. Journal of the Formosan Medical Association. 2006;105(8):626–635. doi: 10.1016/s0929-6646(09)60161-3. - DOI - PubMed

[9] Jensen M. D., Ryan D. H., Apovian C. M., et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults. Journal of the American College of Cardiology. 2014;63(25):2985–3023. doi: 10.1016/j.jacc.2013.11.004. - DOI - PubMed

[10] Jensen M. D., Ryan D. H., Apovian C. M., et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults. Journal of the American College of Cardiology. 2014;63(25):2985–3023. doi: 10.1016/j.jacc.2013.11.004. - DOI - PubMed

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The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity

Affiliations

The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity

Authors

Affiliations

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