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Review
. 2021 May 11:2021:5569274.
doi: 10.1155/2021/5569274. eCollection 2021.

Progress of Interference of Traditional Chinese Medicine on Cirrhosis Treated with Bone Marrow Mesenchymal Stem Cells

Yaxin Wang  1 , Huicun Zhang  1   2 , Hongbing Wang  1   3
Affiliations
Review

Progress of Interference of Traditional Chinese Medicine on Cirrhosis Treated with Bone Marrow Mesenchymal Stem Cells

Yaxin Wang et al. Evid Based Complement Alternat Med. .

Abstract

Transplantation of bone marrow mesenchymal stem cells has attracted more and more attention as a regenerative therapy for the treatment of liver diseases. A large number of studies have shown that this kind of cells can inhibit the activation of hepatic stellate cells and regulate tissue homeostasis and immune system via a variety of ways. Meanwhile, bone marrow mesenchymal stem cells can inhibit apoptosis of hepatocyte, improve liver function, and reduce inflammation through multiple pathways. These cells have a broad prospect in the treatment of liver cirrhosis. At present, there are many studies on the specific mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis. This paper reviews the pathogenesis of liver cirrhosis and the mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis, discusses the effectiveness of traditional Chinese medicine method in enhancing the efficacy of bone marrow mesenchymal stem cells transplantation, and looks forward to its application prospect in the future.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

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References

    1. Nishikawa K., Osawa Y., Kimura K. Wnt/β-Catenin signaling as a potential target for the treatment of liver cirrhosis using antifibrotic drugs. International Journal of Molecular Sciences. 2018;19(10):p. 3103. doi: 10.3390/ijms19103103. - DOI - PMC - PubMed
    1. Rybicka M., Woziwodzka A., Sznarkowska A., et al. Liver cirrhosis in chronic hepatitis b patients is associated with genetic variations in DNA repair pathway genes. Cancers. 2020;12(11):p. 3295. doi: 10.3390/cancers12113295. - DOI - PMC - PubMed
    1. Linecker M., Krones T., Berg T., et al. Potentially inappropriate liver transplantation in the era of the “sickest first” policy - a search for the upper limits. Journal of Hepatology. 2018;68(4):798–813. doi: 10.1016/j.jhep.2017.11.008. - DOI - PubMed
    1. Zhang S., Yang Y., Fan L., Zhang F., Li L. The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future. Annals of Translational Medicine. 2020;8(8):p. 565. doi: 10.21037/atm.2020.03.218. - DOI - PMC - PubMed
    1. Friedenstein A. J., Gorskaja J. F., Kulagina N. N. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Experimental Hematology. 1976;4(5):267–274. - PubMed

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