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. 2021 Apr 29;16(2):151-157.
doi: 10.18502/jovr.v16i2.9077. eCollection 2021 Apr-Jun.

Long-term Outcomes of Collagen Crosslinking for Early Keratoconus

Akbar Derakhshan  1   2 , Javad Heravian  3   4 , Milad Abdolahian  4   5 , Shahram Bamdad  5
Affiliations

Long-term Outcomes of Collagen Crosslinking for Early Keratoconus

Akbar Derakhshan et al. J Ophthalmic Vis Res. .

Abstract

Purpose: To evaluate the long-term outcomes of collagen crosslinking in early keratoconus.

Methods: Thirty eyes of twenty patients with early keratoconus were enrolled. Uncorrected visual acuity (UCVA), best spectacle corrected visual acuity (BSCVA), objective refraction, subjective refraction, corneal topography and pachymetry were assessed before and 3, 6, 12 months and 9 years after performing collagen crosslinking surgery.

Results: The patients' mean age was 31.2 ± 5.59 years at nine-year follow-up (range, 25-44 years). The means of preoperative UCVA and BSCVA were 0.57 ± 0.34 and 0.15 ± 0.12 logMAR, respectively, and these values remained stable at the final follow-up (P = 0.990 and P = 0.227, respectively). The mean objective spherical equivalent decreased considerably from -6.00 ± 4.05 D preoperatively to -5.22 ± 3.71 D at the final follow-up (P < 0.05). The mean subjective spherical equivalent was -4.25 ± 2.87 D preoperatively and this value was stable at the last follow-up (P = 0.92). No considerable difference was found between the post- and preoperative mean objective cylinder values (P = 0.34). The mean subjective cylinder value changed significantly from -4.05 ± 1.85 D preoperatively to -3.1 ± 1.42 D at the final follow-up (P < 0.05). The mean central corneal thickness was 496.97 ± 45.95 µm preoperatively and this value was stable at nine-year follow-up (P = 0.183). No significant difference was found between the pre- and postoperative mean maximum and mean minimum corneal curvature values (P = 0.429 and P = 0.248, respectively). There were no significant postoperative complications.

Conclusion: Corneal crosslinking in early keratoconus seems to be a safe procedure that can effectively stabilize UCVA, BSCVA, subjective SE and CCT, while improving objective spherical equivalent.

Keywords: Collagen Crosslinking; Keratoconus; Cornea.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Stability of logMAR UCVA and logMAR BSCVA after corneal CXL.
Figure 2
Figure 2
Changes in objective and subjective refraction (diopter).
Figure 3
Figure 3
Changes in CCT (µm).
See this image and copyright information in PMC

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References

    1. Mrazovac D, Barišić Kutija M, Vidas S, Kuzman T, Petriček I, Jandroković S, et al. Contact Lenses as the best Conservative Treatment of Newly Diagnosed Keratoconus–Epidemiological Retrospective Study. Coll Antropol 2014;38:1115–1118. - PubMed
    1. Cannon D, Foster C. Collagen crosslinking in keratoconus. Invest Ophthalmol Vis Sci 1978;17:63–65. - PubMed
    1. Hellstedt T, Mäkelä J, Uusitalo R, Emre S, Uusitalo R. Treating keratoconus with Intacs corneal ring segments. J Refract Surg 2005;21:236–246. - PubMed
    1. Richard JM, Paton D, Gasset AR. A comparison of penetrating keratoplasty and lamellar keratoplasty in the surgical management of keratoconus. Am J Ophthalmol 1978;86:807–811. - PubMed
    1. Wood TO. Lamellar transplants in keratoconus. Am J Ophthalmol 1977;83:543–545. - PubMed

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