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Review
. 2021 Apr 10;8(5):ofab180.
doi: 10.1093/ofid/ofab180. eCollection 2021 May.

SARS-CoV-2 Vaccination During Pregnancy: A Complex Decision

Elizabeth Wenqian Wang  1 , Jacqueline G Parchem  2 , Robert L Atmar  3 , Eva H Clark  3   4
Affiliations
Review

SARS-CoV-2 Vaccination During Pregnancy: A Complex Decision

Elizabeth Wenqian Wang et al. Open Forum Infect Dis. .

Abstract

As the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines passed UK and US regulatory milestones in late 2020 and early 2021, multiple professional societies offered recommendations to assist pregnant and breastfeeding people as they choose whether to undergo vaccination. Despite such guidance, the lack of data describing vaccine safety, immunogenicity, and efficacy in pregnant and breastfeeding people has made this decision challenging for many. However, even considering the paucity of data, the known risks of coronavirus disease 2019 during pregnancy likely outweigh the not yet fully elucidated risks of SARS-CoV-2 vaccines, which have reassuring safety and efficacy profiles among nonpregnant people.

Keywords: COVID-19; SARS-CoV-2; breastfeeding; pregnancy; vaccine.

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