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Review
. 2021 Jul 1;321(1):E169-E175.
doi: 10.1152/ajpendo.00558.2020. Epub 2021 May 31.

Fight against fibrosis in adipose tissue remodeling

Siqi Li  1   2   3 , Hongxia Gao  2 , Yutaka Hasegawa  4 , Xiaodan Lu  1   2   3
Affiliations
Review

Fight against fibrosis in adipose tissue remodeling

Siqi Li et al. Am J Physiol Endocrinol Metab. .

Abstract

Adipose is a key tissue regulating energy homeostasis. In states of obesity, caloric intake exceeds energy expenditure, thereby accelerating lipid accumulation with ongoing extracellular matrix (ECM) remodeling. Excess deposition of lipids and expansion of adipocytes potentially decrease ECM flexibility with local hypoxia and inflammation. Hypoxia and chronic low-grade inflammation accelerate the development of adipose tissue fibrosis and related metabolic dysfunctions. Recent research investigated that some cytokines and proteins are functional in regulating energy homeostasis, meanwhile, are potential targets to fight against adipose tissue fibrosis and insulin resistance. In this review, we focused on the regulatory mechanisms and mediators in remodeling of adipose tissue fibrosis, along with their relevance to clinical manifestations.

Keywords: ECM; adipose tissue; diabetes; fibrosis; mitochondria.

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Figures

None
Graphical abstract
Figure 1.
Figure 1.
Adipose tissue remodeling during obesity. With increased food intake, adipose tissue undergoes appropriate expansion through hypertrophy and hyperplasia. Adipose tissue remodeling impacts localized adipose tissue metabolism, which including adipogenesis, angiogenesis, insulin sensitivity, cytokine secretion profile, and in turn alters systemic glucose and lipid homeostasis. The activation and maintenance of beige adipocyte is a potential therapeutic strategy for combating adipose tissue fibrosis and insulin resistance.
See this image and copyright information in PMC

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