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. 2021 May;49(5):3000605211017724.
doi: 10.1177/03000605211017724.

Relationship between dietary factors and recurrent aphthous stomatitis in China: a cross-sectional study

Kaiyuan Xu  1 , Chongchong Zhou  1 , Fan Huang  1 , Ning Duan  1 , Yanyi Wang  1 , Lichun Zheng  1 , Xiang Wang  1 , Wenmei Wang  1
Affiliations

Relationship between dietary factors and recurrent aphthous stomatitis in China: a cross-sectional study

Kaiyuan Xu et al. J Int Med Res. 2021 May.

Abstract

Objective: Recurrent aphthous stomatitis (RAS), a common oral mucosal disorder characterized by chronic, inflammatory, and ovoid ulcers, has a complex etiology. The purpose of the study was to investigate the specific dietary factors influencing the prevalence of RAS.

Methods: A total of 754 participants aged 18 to 59 years were enrolled in this descriptive cross-sectional study. An anonymous questionnaire was adopted to investigate the distribution of RAS, dietary factors, self-reported trigger factors, and therapeutic methods.

Results: Among all participants, the prevalence rate of RAS was 21.4%. Univariable analysis showed that fruit, dairy products, vegetables, and water, but not fried foods, fermented foods, spicy foods, and eggs, were preventive factors against RAS. After adjusting for age and sex, multivariable regression analysis suggested that fruit (adjusted odds ratio [aOR] = 0.430, 95% confidence interval [CI] = 0.218-0.847) and water (aOR = 0.294, 95% CI = 0.119-0.726) were protective factors against RAS.

Conclusion: This study found that the consumption of fruit and water was negatively associated with RAS. These results imply a potential adjunctive and complementary role of food in RAS treatment and some feasible means of RAS prevention.

Keywords: Recurrent aphthous stomatitis; cross-sectional study; dietary habit; prevalence; preventive factor; treatment.

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Conflict of interest statement

Declaration of conflicting interest: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Distribution of trigger factors in the different age groups
Figure 2.
Figure 2.
Distribution of rates of recurrent aphthous stomatitis (RAS) in groups with different dietary habits, including consumption of fruit, dairy products, and vegetables (A), water (B), and spicy foods, high-temperature foods, fried foods, and fermented foods (C)
Figure 3.
Figure 3.
Multivariable logistic regression of the relationship between dietary factors and recurrent aphthous stomatitis aAdjusted for age and sex.
See this image and copyright information in PMC

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