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. 2021 Aug;21(8):2919-2921.
doi: 10.1111/ajt.16702. Epub 2021 Jun 18.

Impaired anti-SARS-CoV-2 humoral and cellular immune response induced by Pfizer-BioNTech BNT162b2 mRNA vaccine in solid organ transplanted patients

Monica Miele  1   2 , Rosalia Busà  1 , Giovanna Russelli  1 , Maria Concetta Sorrentino  1 , Mariangela Di Bella  1   2 , Francesca Timoneri  1   2 , Alessandra Mularoni  1 , Giovanna Panarello  1 , Patrizio Vitulo  1 , Pier Giulio Conaldi  1 , Matteo Bulati  1
Affiliations

Impaired anti-SARS-CoV-2 humoral and cellular immune response induced by Pfizer-BioNTech BNT162b2 mRNA vaccine in solid organ transplanted patients

Monica Miele et al. Am J Transplant. 2021 Aug.
No abstract available

Keywords: clinical research/practice; immunobiology; infection and infectious agents-viral; infectious disease; organ transplantation in general; vaccine.

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Figures

FIGURE 1
FIGURE 1
(A) Anti-SARS-CoV-2 S1/S2 IgG concentration in solid organ transplant recipients (SOTRs) (n = 16) compared to ICs (n = 23). The horizontal bars correspond to the median value, respectively, 3.8 AU/ml in SOTRs and 212 AU/ml in immunocompetent subjects (ICs). Samples with anti-SARS-CoV-2 S1/S2 IgG concentration >15 AU/ml were considered positive. The dotted line corresponds to threshold. (B) T cell responses (IFN-γ ELISpot SFC per 106 PBMC) to Spike (Mix I and II, respectively, of 158 and 157 peptides derived from a peptide scan, 15mers with 11 aa overlap) (p < .0001), or CEF (p = .08), were compared between ICs (n = 23) and SOTRs (n = 16). Each dot plot represents normalized mean spot count from duplicate wells (2.5 ± 0.5 × 105 PBMC/well) for each subject, after subtraction of spots count of unstimulated cells (the medium with peptides pool diluent-only). Circles under the graphics are representative of ELISpot from each group against Spike and CEF peptide pools. Bold black line represents the median and dotted line the experimental threshold (95 SFC per 106 PBMC). The significance was determined using a Mann-Whitney U-test (two-sides), ****p < .0001
See this image and copyright information in PMC

References

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