Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Claire E Sexton¹, Kaarin J Anstey², Filippo Baldacci^{3

4}, C J Barnum⁵, Anna M Barron⁶, Kaj Blennow^{7

8}, Henry Brodaty⁹, Samantha Burnham¹⁰, Fanny M Elahi¹¹, Jürgen Götz¹², Yun-Hee Jeon¹³, Maya Koronyo-Hamaoui¹⁴, Susan M Landau¹⁵, Nicola T Lautenschlager^{16

17}, Simon M Laws¹⁸, Darren M Lipnicki⁹, Hanzhang Lu¹⁹, Colin L Masters²⁰, Wendy Moyle²¹, Akinori Nakamura²², Giulio Maria Pasinetti²³, Naren Rao²⁴, Christopher Rowe^{20

25}, Perminder S Sachdev^{9

26}, Peter R Schofield²⁷, Einar M Sigurdsson²⁸, Kate Smith²⁹, Velandai Srikanth³⁰, Cassandra Szoeke³¹, Malú G Tansey³², Rachel Whitmer³³, Donna Wilcock³⁴, Tien Y Wong³⁵, Lisa J Bain³⁶, Maria C Carrillo¹

Affiliations

¹ Alzheimer's Association, Chicago, Illinois, USA.
² University of New South Wales and Neuroscience Research, Sydney, NSW, Australia.
³ Unit of Neurology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
⁴ GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
⁵ INmune Bio Inc., La Jolla, CA, USA.
⁶ Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.
⁷ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
⁸ Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
⁹ Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia.
¹⁰ CSIRO Health & Biosecurity, The Australian e-Health Research Centre, Parkville, VIC, Australia.
¹¹ Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
¹² Clem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, St Lucia Campus (Brisbane), Brisbane, QLD, Australia.
¹³ The University of Sydney, Sydney, NSW, Australia.
¹⁴ Departments of Neurosurgery and Biomedical Sciences, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
¹⁵ University of California Berkeley, Berkeley, California, USA.
¹⁶ Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
¹⁷ North Western Mental Health, Royal Melbourne Hospital, Melbourne, Australia.
¹⁸ Collaborative Genomics and Translation Group, Edith Cowan University, Joondalup, WA, Australia.
¹⁹ Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
²⁰ The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
²¹ Menzies Health Institute Queensland, Griffith University, Griffith, QLD, Australia.
²² Department of Biomarker Research, National Center for Geriatrics and Gerontology, Obu, Japan.
²³ Department of Neurology, Icahn School of Medicine at Mount Sinai (ISSMS), New York, New York, USA.
²⁴ Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India.
²⁵ Department of Molecular Imaging, Austin Health, Melbourne, VIC, Australia.
²⁶ Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia.
²⁷ Neuroscience Research Australia, Sydney and School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.
²⁸ Departments of Neuroscience and Physiology, and Psychiatry, Neuroscience Institute, New York University Grossman School of Medicine, New York, New York, USA.
²⁹ Centre for Aboriginal Medical and Dental Health, University of Western Australia, Crawley, WA, Australia.
³⁰ Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, VIC, Australia.
³¹ University of Melbourne, VIC, Australia.
³² Departments of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, Normal Fixel Center for Neurological Diseases, University of Florida College of Medicine, Gainesville, Florida, USA.
³³ Department of Public Health Sciences, University of California, Davis, Davis, California, USA.
³⁴ Sanders-Brown Center on Aging and Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
³⁵ Singapore Eye Research Institute, Singapore National Eye Center, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
³⁶ Independent Science Writer, Elverson, Pennsylvania, USA.

PMID: 34058063
PMCID: PMC9396711
DOI: 10.1002/alz.12380

Review

Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Claire E Sexton et al. Alzheimers Dement. 2022 Jan.

. 2022 Jan;18(1):178-190.

doi: 10.1002/alz.12380. Epub 2021 May 31.

Authors

Affiliations

¹ Alzheimer's Association, Chicago, Illinois, USA.
² University of New South Wales and Neuroscience Research, Sydney, NSW, Australia.
³ Unit of Neurology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
⁴ GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
⁵ INmune Bio Inc., La Jolla, CA, USA.
⁶ Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.
⁷ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
⁸ Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
⁹ Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia.
¹⁰ CSIRO Health & Biosecurity, The Australian e-Health Research Centre, Parkville, VIC, Australia.
¹¹ Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
¹² Clem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, St Lucia Campus (Brisbane), Brisbane, QLD, Australia.
¹³ The University of Sydney, Sydney, NSW, Australia.
¹⁴ Departments of Neurosurgery and Biomedical Sciences, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
¹⁵ University of California Berkeley, Berkeley, California, USA.
¹⁶ Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
¹⁷ North Western Mental Health, Royal Melbourne Hospital, Melbourne, Australia.
¹⁸ Collaborative Genomics and Translation Group, Edith Cowan University, Joondalup, WA, Australia.
¹⁹ Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
²⁰ The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
²¹ Menzies Health Institute Queensland, Griffith University, Griffith, QLD, Australia.
²² Department of Biomarker Research, National Center for Geriatrics and Gerontology, Obu, Japan.
²³ Department of Neurology, Icahn School of Medicine at Mount Sinai (ISSMS), New York, New York, USA.
²⁴ Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India.
²⁵ Department of Molecular Imaging, Austin Health, Melbourne, VIC, Australia.
²⁶ Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia.
²⁷ Neuroscience Research Australia, Sydney and School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.
²⁸ Departments of Neuroscience and Physiology, and Psychiatry, Neuroscience Institute, New York University Grossman School of Medicine, New York, New York, USA.
²⁹ Centre for Aboriginal Medical and Dental Health, University of Western Australia, Crawley, WA, Australia.
³⁰ Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, VIC, Australia.
³¹ University of Melbourne, VIC, Australia.
³² Departments of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, Normal Fixel Center for Neurological Diseases, University of Florida College of Medicine, Gainesville, Florida, USA.
³³ Department of Public Health Sciences, University of California, Davis, Davis, California, USA.
³⁴ Sanders-Brown Center on Aging and Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
³⁵ Singapore Eye Research Institute, Singapore National Eye Center, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
³⁶ Independent Science Writer, Elverson, Pennsylvania, USA.

PMID: 34058063
PMCID: PMC9396711
DOI: 10.1002/alz.12380

Abstract

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal lifestyle intervention studies have been launched in Australia; and Australian researchers have played leadership roles in other global studies in diverse populations. Australian researchers have also played an instrumental role in efforts to understand mechanisms underlying vascular contributions to cognitive impairment and dementia; and through the Women's Healthy Aging Project have elucidated hormonal and other factors that contribute to the increased risk of AD in women. Alleviating the behavioral and psychological symptoms of dementia has also been a strong research and clinical focus in Australia.

Keywords: Alzheimer's; behavioral symptoms; biomarkers; dementia; prevention.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST

K. Anstey is an advisor for StaySharp. CJ. Barnum is a full-time employee and stockholder at INmune Bio Inc. K. Blennow has served as a consultant, on advisory boards, or on data monitoring committees for Abcam, Axon, Biogen, JOMDD/Shimadzu, Julius Clinical, Lilly, MagQu, Novartis, Roche Diagnostics, and Siemens Healthineers, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program. H. Brodaty is a member of the Advisory Board, Nutricia Australia. S. Burnham, Patent: Method for detection of a neurological disease 2014. M.C. Carrillo and C.E. Sexton are full-time employees of the Alzheimer’s Association. M. Koronyo-Hamaoui is a co-founding member and a consultant of NeuroVision Imaging Inc. S. Landau has consulted for NeuroVision and Cortexyme. S. Laws is a member of an advisory panel, Cytox Ltd. C.Rowe is on advisory boards for Biogen Australia, Cerveau Technologies Research Grants from Eisai, Biogen, Enigma, Abbvie. P. Sachdev is on the advisory committee for Biogen Australia. E.M. Sigurdsson has served as a consultant for H. Lundbeck A/S, Biogen, and GlaxoSmithKline, and received seminar fees from Merck, Bristol Myers Squibb, and Voyager Therapeutics. He is an inventor on several patents that are assigned to New York University. Some of the patents on tau immunotherapy and related diagnostics are licensed to and are being co-developed by H. Lundbeck A/S. C. Szoeke has provided clinical consultancy and been on scientific advisory committees for the Australian Commonwealth Scientific and Industrial Research Organisation and other relationships that are subject to confidentiality clauses. D. Wilcock is a paid consultant for AC Immune, Alector, and Eisai Inc. None of the work presented is related to these agreements. M. Tansey serves on the Michael J. Fox Foundation for Parkinson’s Research Emerging Targets Advisory Committee, on the W.Weston Garfield Brain Institute Advisory Board, the Quebec Parkinson’s Network, World Parkinson Coalition Board, Alzheimer’s Association Medical and Scientific Advisory Group, and is a consultant to INmune Bio., Longevity Bio, Cerebral Therapeutics, RegeneX, and Prevail Therapeutics.

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Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Affiliations

Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Authors

Affiliations

Abstract

Conflict of interest statement

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