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. 2021 Jul;78(1):40-50.
doi: 10.1161/HYPERTENSIONAHA.121.17001. Epub 2021 Jun 1.

Reservoir-Excess Pressure Parameters Independently Predict Cardiovascular Events in Individuals With Type 2 Diabetes

Kunihiko Aizawa  1 , Francesco Casanova  1 , Phillip E Gates  1 , David M Mawson  1 , Kim M Gooding  1 , W David Strain  1 , Gerd Östling  2 , Jan Nilsson  2 , Faisel Khan  3 , Helen M Colhoun  4 , Carlo Palombo  5 , Kim H Parker  6 , Angela C Shore  1 , Alun D Hughes  7
Affiliations

Reservoir-Excess Pressure Parameters Independently Predict Cardiovascular Events in Individuals With Type 2 Diabetes

Kunihiko Aizawa et al. Hypertension. 2021 Jul.

Abstract

[Figure: see text].

Keywords: aging; blood pressure; cardiovascular disease; hemodynamics; risk factor.

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Conflict of interest statement

c. Disclosure: No potential conflicts of interest relevant to this article were reported.

Figures

Figure 1
Figure 1
A schematic representation of reservoir-excess pressure separation in the radial artery. INTPR, reservoir pressure integral; MAXPR, peak reservoir pressure; INTXSP, excess pressure integral; SRC, systolic rate constant; DRC, diastolic rate constant. Adapted from Davies et al.
Figure 2
Figure 2
Comparisons of reservoir-excess pressure parameters among the groups at baseline. The data are shown as medians (95% confidence intervals). DMCVD, type 2 diabetes with cardiovascular disease group; DM, type 2 diabetes group; CTRL, control group; INTPR, reservoir pressure integral; MAXPR, peak reservoir pressure; INTXSP, excess pressure integral; SRC, systolic rate constant; DRC, diastolic rate constant.
Figure 3
Figure 3
Logistic regression analysis of reservoir-excess pressure parameters, and conventional central and peripheral artery hemodynamic parameters for predicting cardiovascular events in individuals with type 2 diabetes. A: Results of a minimally adjusted (age and sex) logistic regression analysis of reservoir-excess pressure parameters. B: Results of a minimally adjusted (age and sex) logistic regression analysis of conventional central and peripheral artery hemodynamic parameters. C: Results of multivariate logistic regression analysis of reservoir-excess pressure parameters. D: Results of multivariate logistic regression analysis of conventional central and peripheral artery hemodynamic parameters. In C and D, age, sex, total and HDL cholesterol, current smoking, systolic blood pressure, pharmacological hypertensive treatment at baseline, and study centre were included in the model in addition to each reservoir-excess pressure parameter, and conventional central and peripheral artery hemodynamic parameters. INTPR, reservoir pressure integral; MAXPR, peak reservoir pressure; INTXSP, excess pressure integral; SRC, systolic rate constant; DRC, diastolic rate constant; CSBP, central systolic blood pressure; CDBP, central diastolic blood pressure; CPP, central pulse pressure; CAP, central augmented pressure; CAIx@HR75, central augmentation index adjusted for heart rate 75 beat per min; BSBP, brachial systolic blood pressure; BPP, brachial pulse pressure.
See this image and copyright information in PMC

References

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