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Observational Study
. 2021 Jul;78(1):65-73.
doi: 10.1161/HYPERTENSIONAHA.120.16692. Epub 2021 Jun 1.

Mean Arterial Pressure and Chronic Kidney Disease Progression in the CKiD Cohort

Janis M Dionne  1 , Shuai Jiang  2 , Derek K Ng  2 , Joseph T Flynn  3 , Mark M Mitsnefes  4 , Susan L Furth  5 , Bradley A Warady  6 , Joshua A Samuels  7 ; CKiD study group
Affiliations
Observational Study

Mean Arterial Pressure and Chronic Kidney Disease Progression in the CKiD Cohort

Janis M Dionne et al. Hypertension. 2021 Jul.

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT00327860.

Keywords: arterial pressure; blood pressure; disease progression; pediatrics; proteinuria.

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Conflict of interest statement

Disclosures

The authors have no conflicts to disclose.

Figures

Figure 1.
Figure 1.
Survival functions of time to renal replacement therapy (RRT) or 50% decline in GFR by ambulatory MAP percentile category, stratified by non-glomerular and glomerular diagnoses.
Figure 2.
Figure 2.
Relative hazards of renal replacement therapy or 50% decline in GFR by MAP percentile categories, stratified by non-glomerular (◼) and glomerular (▲) diagnoses. Results are presented unadjusted, minimally adjusted for age, gender and race, and adjusted for age, gender, race and proteinuria level (uPrCr). For children with non-glomerular diagnosis, time-varying risk was characterized by ≤ 4 years and > 4 years from baseline. No significant time-varying risk was observed among children with glomerular diagnoses.
Figure 3.
Figure 3.
Proportion of ACEi/ARB therapy use by MAP percentile category and visit, stratified by non-glomerular and glomerular diagnosis. Within each cell, the size of the shaded polygon is proportional to those using ACEi/ARB therapy. Darker shaded polygons indicate higher number of participants in each cell.
See this image and copyright information in PMC

References

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