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. 2021 May 31;7(1):115.
doi: 10.1186/s40814-021-00859-3.

Brain stimulation in attention deficits after traumatic brain injury: a literature review and feasibility study

Ève Boissonnault  1   2   3 , Johanne Higgins  4   5   6 , Geneviève LaGarde  4   5 , Dorothy Barthélemy  4   5   6 , Céline Lamarre  7   4   5 , Jehane H Dagher  7   4   5
Affiliations

Brain stimulation in attention deficits after traumatic brain injury: a literature review and feasibility study

Ève Boissonnault et al. Pilot Feasibility Stud. .

Abstract

Background: After a traumatic brain injury, disturbances in the attentional processes have a direct negative effect on functional recovery and on return to complex activities. To date, there is no good attention remediation treatment available. The primary objective of this review and pilot study is to provide an overview of the research evidence and to evaluate the feasibility of implementing a tDCS protocol to improve attention disorders in patients with mild complicated to severe subacute TBI, hospitalized in an inpatient rehabilitation facility. Our secondary objective is to extract preliminary data and observational information on participants' response to treatment.

Methods: Participants were recruited from a consecutive series of patients admitted to the TBI unit of a subspecialized regional rehabilitation center. They received a 20-min tDCS stimulation 3 times a week for 3 weeks. A neuropsychological evaluation was performed before and after the intervention. We collected participants' sociodemographic and clinical characteristics as well as information about satisfaction, tolerability, and adverse effects.

Results: One hundred sixty-four patients were admitted between September 2018 and January 2020. One hundred fifty-eight were excluded, and 6 patients with presumed attentional deficits were enrolled. None completed the protocol as intended. No major side effects occurred.

Conclusion: Non-invasive brain neurostimulation is promising to enhance attention deficits in patients with TBI. Implementation of a tDCS protocol to fulfill this purpose in an intensive inpatient rehabilitation center has its limitations. We made recommendations to facilitate the implementation of similar projects in the future.

Trial registration: ISRCTN, ISRCTN55243064 . Registered 14 October 2020-retrospectively registered.

Keywords: Attention; Brain injuries, Traumatic; Rehabilitation; Transcranial direct current stimulation; Transcranial magnetic stimulation.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Exclusions and refusals
Fig. 2
Fig. 2
Study flow diagram
See this image and copyright information in PMC

References

    1. Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Injury Prevention and Control; Administration for Community Living (ACL) National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR): One and five year outcomes after moderate-to-severe traumatic brain injury requiring inpatient rehabilitation: traumatic brain injury report. U.S: Stephen B. Thacker CDC Library collection; 2018.
    1. McKee AC, Daneshvar DH. The neuropathology of traumatic brain injury. Handb Clin Neurol. 2015;127:45–66. doi: 10.1016/B978-0-444-52892-6.00004-0. - DOI - PMC - PubMed
    1. Demirtas-Tatlidede A, Vahabzadeh-Hagh AM, Bernabeu M, Tormos JM, Pascual-Leone A. Noninvasive brain stimulation in traumatic brain injury. J Head Trauma Rehabil. 2012;27(4):274–292. doi: 10.1097/HTR.0b013e318217df55. - DOI - PMC - PubMed
    1. Kim WS, Lee K, Kim S, Cho S, Paik NJ. Transcranial direct current stimulation for the treatment of motor impairment following traumatic brain injury. J Neuroeng Rehabil. 2019;16(1):14. doi: 10.1186/s12984-019-0489-9. - DOI - PMC - PubMed
    1. Rabinowitz AR, Levin HS. Cognitive sequelae of traumatic brain injury. Psychiatr Clin North Am. 2014;37(1):1–11. doi: 10.1016/j.psc.2013.11.004. - DOI - PMC - PubMed

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