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Comment
. 2021 Jun 1:10:e69680.
doi: 10.7554/eLife.69680.

A move in response to starvation

Rebecca Martina Fausten  1 , Maria Bohnert  1
Affiliations
Comment

A move in response to starvation

Rebecca Martina Fausten et al. Elife. .

Abstract

When a yeast cell runs out of fuel, it can increase the flux through a central metabolic pathway by simply changing the location of an enzyme.

Keywords: HMG-CoA Reductase; S. cerevisiae; cell biology; lipid droplet; mevalonate; nucleus-vacuole junction; sterol-ester.

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Conflict of interest statement

RF, MB No competing interests declared

Figures

Figure 1.
Figure 1.. Enzyme partitioning in the mevalonate pathway.
The enzyme HMG-CoA reductase (orange) is dispersed throughout the membrane of the endoplasmic reticulum (brown) in the presence of ample glucose (left), but it moves to a contact site between the cell nucleus and a lysosome-like organelle called the vacuole (green) in response to glucose deprivation (center). This nucleus-vacuole junction depends on two tether proteins, Vac8 (blue) and Nvj1 (red). The partitioning of HMG-CoA reductase to the contact site results in increased flux through the mevalonate pathway (right), and growth advantages once glucose becomes available again.
See this image and copyright information in PMC

Comment on

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