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. 2021;12(4):1511-1513.e2.
doi: 10.1016/j.jcmgh.2021.05.016. Epub 2021 May 29.

A Novel Noninvasive Method Based on Salivary Inflammatory Biomarkers for the Screening of Celiac Disease

M Sebastian-delaCruz  1 , A Olazagoitia-Garmendia  1 , A Huerta Madrigal  2 , K Garcia-Etxebarria  3 , L M Mendoza  4 , N Fernandez-Jimenez  1 , Z Garcia Casales  5 , E de la Calle Navarro  5 , A E Calvo  5 , M Legarda  6 , C Tutau  6 , I Irastorza  6 , L Bujanda  7 , J R Bilbao  8 , A Castellanos-Rubio  9
Affiliations

A Novel Noninvasive Method Based on Salivary Inflammatory Biomarkers for the Screening of Celiac Disease

M Sebastian-delaCruz et al. Cell Mol Gastroenterol Hepatol. 2021.
No abstract available

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Figures

Figure 1
Figure 1
Heatmaps of (A) the inflammatory biomarkers expressed in small intestine and saliva (n = 6) and of the 8 selected genes in the (B) small intestine or (C) saliva from active celiac patients (n = 18) and controls (n = 21). Expression values were normalized against the average expression of each gene. Differential expression of the genes CXCL1 and IL1B in the (D) small intestine and (E) saliva samples from active celiac patients celiac disease (CD) (N = 18) and controls (Ctrl) (n = 21). ∗∗P < .01; ∗P < .05; +P < .1 by Student t test. (F) Pearson correlation (r) of CXCL1 (grey dots) and IL1B (black dots) expression between small intestine and saliva samples (n = 39).
Figure 2
Figure 2
Receiver operating characteristic (ROC) plot of the combinatory logistic regression model including gene expression and HLA genotype in the (A) evaluation cohort (n = 39) and (C) confirmation cohort (N = 100). Comparison of the combinatory logistic regression values between celiac patients (celiac disease [CD]) and controls (Ctrl) in the (B) evaluation cohort (n = 39) and (D) confirmation cohort (n = 100). ∗∗P < .01 by Student t test.
Supplementary Figure 1
Supplementary Figure 1
Receiver operating characteristic (ROC) plot of the individual gene expression values of (A) CXCL1 and (B) IL1B in the evaluation cohort (n = 39). (C) ROC plot of the combinatory logistic regression model of the expression of both genes in the evaluation cohort (n = 39). (D) Comparison of the combinatory logistic regression values using gene expression between celiac disease patients (CD) and controls (Ctrl) in the evaluation cohort (n = 39). ∗∗P < .01 based on an unpaired Student t test. AUC, area under the curve.
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References

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