Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May 1;57(5):438.
doi: 10.3390/medicina57050438.

Recombinant Human Adenovirus- p53 Therapy for the Treatment of Oral Leukoplakia and Oral Squamous Cell Carcinoma: A Systematic Review

Affiliations

Recombinant Human Adenovirus- p53 Therapy for the Treatment of Oral Leukoplakia and Oral Squamous Cell Carcinoma: A Systematic Review

Jagadish Hosmani et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Oral cancer is the 6th most common cancer in the world and oral leukoplakia is an oral potentially malignant disorder that could develop into oral cancer. This systematic review focusses on randomized clinical trials for recombinant adenovirus p-53 (rAD-p53) therapy for the treatment of oral leukoplakia and cancer. Materials and Methods: We searched for research articles on various databases such as Pubmed/Medline, Embase, CNKI (China National Knowledge Infra-structure), Springerlink, cochrane and Web of sciences from 2003 to 2020. MeSH (Medical Subject Headings) terms were used for the search. Inclusion criteria included original research, randomized clinical trials and articles only in English language. Exclusion criteria were any articles that were not research articles, not randomized trials, non-human studies, etc. The articles were further graded on the Jadad scale. Results: 578 articles were assessed from various databases; only 3 articles were found to be appropriate for this review. Thus, meta-analysis was not performed because of heterogeneity and lack of data. In the three studies, whether rAD-p53 was used as a standalone therapy or with other therapies, there was a beneficial effect of the therapy. Furthermore, there were no serious adverse events and the only adverse events reported were fever, pain at the local injection site, flu-like symptoms and lowered WBC count. Conclusions: Thus, we can conclude that this therapy has a potential for beneficial therapeutic effects and further clinical trials with more patients need to be performed to get better understanding of the effect of rAD-p53 therapy, which probably will pave the way to its approval in other parts of the world.

Keywords: gendicine; gene therapy; oral Leukoplakia; oral squamous cell carcinoma; rAD-p53 therapy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The flowchart showing database literature search and the method of shortlisting articles for review.
Figure 2
Figure 2
Modified Jadad questionnaire.

Similar articles

Cited by

References

    1. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009;45:309–316. doi: 10.1016/j.oraloncology.2008.06.002. - DOI - PubMed
    1. Van der Waal I. Oral leukoplakia, the ongoing discussion on definition and terminology. Med. Oral Patol. Oral Cir. Bucal. 2015;20:e685–e692. doi: 10.4317/medoral.21007. - DOI - PMC - PubMed
    1. Van der Waal I., Schepman K.P., van der Meij E.H., Smeele L.E. Oral leukoplakia: A Clinicopathological review. Oral Oncol. 1997;33:291–301. doi: 10.1016/S1368-8375(97)00002-X. - DOI - PubMed
    1. Warnakulasuriya S., Johnson N.W., Van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J. Oral Pathol. Med. 2007;36:575–580. doi: 10.1111/j.1600-0714.2007.00582.x. - DOI - PubMed
    1. Scully C. Oral cancer aetiopathogenesis; past, present and future aspects. Med. Oral Patol. Oral Cir. Bucal. 2011;16:306–311. doi: 10.4317/medoral.16.e306. - DOI - PubMed

Publication types

Substances