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Review
. 2021 May 2;10(9):1957.
doi: 10.3390/jcm10091957.

Systemic Lupus Erythematosus and Periodontal Disease: A Complex Clinical and Biological Interplay

Bouchra Sojod  1   2 , Cibele Pidorodeski Nagano  3 , Glenda Melissa Garcia Lopez  1   2 , Antoine Zalcberg  1   2 , Sophie Myriam Dridi  4 , Fani Anagnostou  1   2   3
Affiliations
Review

Systemic Lupus Erythematosus and Periodontal Disease: A Complex Clinical and Biological Interplay

Bouchra Sojod et al. J Clin Med. .

Abstract

Reports on the association of periodontal disease (PD) with systemic lupus erythematosus (SLE) have regularly been published. PD is a set of chronic inflammatory conditions linked to a dysbiotic microbial biofilm, which affects the periodontal tissues, resulting eventually in their destruction and contributing to systemic inflammation. SLE is a multi-system chronic inflammatory autoimmune disease that has a wide range of clinical presentations, touching multiple organ systems. Many epidemiological studies have investigated the two-way relationship between PD and SLE, though their results are heterogeneous. SLE and PD are multifactorial conditions and many biological-based hypotheses suggest common physiopathological pathways between the two diseases, including genetics, microbiology, immunity, and environmental common risk factors. By focusing on recent clinical and translational research, this review aimed to discuss and give an overview of the relationship of SLE with PD, as well as looking at the similarities in the immune-pathological aspects and the possible mechanisms connecting the development and progression of both diseases.

Keywords: autoimmune and inflammatory diseases; periodontal disease; periodontitis; periopathogens; risk factors; systematic lupus erythematosus.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Crampton S.P., Morawski P.A., Bolland S. Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus. Dis. Model. Mech. 2014;7:1033–1046. doi: 10.1242/dmm.016451. - DOI - PMC - PubMed
    1. Moulton V.R., Suarez-Fueyo A., Meidan E., Li H., Mizui M., Tsokos G.C. Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective. Trends Mol. Med. 2017;23:615–635. doi: 10.1016/j.molmed.2017.05.006. - DOI - PMC - PubMed
    1. Khatibi M., Shakoorpour A.H., Jahromi Z.M., Ahmadzadeh A. The prevalence of oral mucosal lesions and related factors in 188 patients with systemic lupus erythematosus. Lupus. 2012;21:1312–1315. doi: 10.1177/0961203312454589. - DOI - PubMed
    1. Benli M., Batool F., Stutz C., Petit C., Jung S., Huck O. Orofacial manifestations and dental management of systemic lupus erythematosus: A review. Oral Dis. 2021;27:151–167. doi: 10.1111/odi.13271. - DOI - PubMed
    1. Rodriguez J.P.L., Torres L.J.G., Martinez R.E.M., Mendoza C.A., Medina-Solís C.E., Coronel S.R., Cortes J.O.G., Pérez R.A.D. Frequency of dental caries in active and inactive systemic lupus erythematous patients: Salivary and bacterial factors. Lupus. 2016;25:1349–1356. doi: 10.1177/0961203316640909. - DOI - PubMed

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