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Review
. 2021 May 21;22(11):5421.
doi: 10.3390/ijms22115421.

Inflammation-Induced Tumorigenesis and Metastasis

Sana Hibino  1 , Tetsuro Kawazoe  2   3 , Hidenori Kasahara  4   5   6 , Shinji Itoh  3 , Takatsugu Ishimoto  7 , Mamiko Sakata-Yanagimoto  8 , Koji Taniguchi  2   9
Affiliations
Review

Inflammation-Induced Tumorigenesis and Metastasis

Sana Hibino et al. Int J Mol Sci. .

Abstract

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how inflammation promotes tumorigenesis and metastasis and suppresses anti-tumor immunity in various types of solid tumors, including esophageal, gastric, colorectal, liver, and pancreatic cancer as well as hematopoietic malignancies.

Keywords: cancer; immunosuppression; inflammation; metastasis; tumor microenvironment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chronic inflammation promotes tumor progression.
See this image and copyright information in PMC

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