Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May 11;11(5):433.
doi: 10.3390/life11050433.

Perfusion Parameters in Near-Infrared Fluorescence Imaging with Indocyanine Green: A Systematic Review of the Literature

Lauren N Goncalves  1 , Pim van den Hoven  1 , Jan van Schaik  1 , Laura Leeuwenburgh  1 , Cas H F Hendricks  1 , Pieter S Verduijn  1 , Koen E A van der Bogt  1 , Carla S P van Rijswijk  1 , Abbey Schepers  1 , Alexander L Vahrmeijer  1 , Jaap F Hamming  1 , Joost R van der Vorst  1
Affiliations
Review

Perfusion Parameters in Near-Infrared Fluorescence Imaging with Indocyanine Green: A Systematic Review of the Literature

Lauren N Goncalves et al. Life (Basel). .

Abstract

(1) Background: Near-infrared fluorescence imaging is a technique capable of assessing tissue perfusion and has been adopted in various fields including plastic surgery, vascular surgery, coronary arterial disease, and gastrointestinal surgery. While the usefulness of this technique has been broadly explored, there is a large variety in the calculation of perfusion parameters. In this systematic review, we aim to provide a detailed overview of current perfusion parameters, and determine the perfusion parameters with the most potential for application in near-infrared fluorescence imaging. (2) Methods: A comprehensive search of the literature was performed in Pubmed, Embase, Medline, and Cochrane Review. We included all clinical studies referencing near-infrared perfusion parameters. (3) Results: A total of 1511 articles were found, of which, 113 were suitable for review, with a final selection of 59 articles. Near-infrared fluorescence imaging parameters are heterogeneous in their correlation to perfusion. Time-related parameters appear superior to absolute intensity parameters in a clinical setting. (4) Conclusions: This literature review demonstrates the variety of parameters selected for the quantification of perfusion in near-infrared fluorescence imaging.

Keywords: indocyanine green; near infrared fluorescence; perfusion imaging.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Preferred reporting items for systematic review and meta-analysis protocols flow chart for the selection of included studies.
Figure 2
Figure 2
Schematic representation I of the perfusion parameters in Table 1.
Figure 3
Figure 3
Schematic Representation II of the perfusion parameters in Table 1.
See this image and copyright information in PMC

References

    1. Cornelissen A.J.M., Van Mulken T.J.M., Graupner C., Qiu S.S., Keuter X.H.A., Van Der Hulst R.R.W.J., Schols R.M. Near-infrared fluorescence image-guidance in plastic surgery: A systematic review. Eur. J. Plast. Surg. 2018;41:269–278. doi: 10.1007/s00238-018-1404-5. - DOI - PMC - PubMed
    1. Hoven P.V.D., Ooms S., van Manen L., van der Bogt K.E., van Schaik J., Hamming J.F., Vahrmeijer A.L., van der Vorst J.R., Mieog J.S.D. A systematic review of the use of near-infrared fluorescence imaging in patients with peripheral artery disease. J. Vasc. Surg. 2019;70:286–297.e1. doi: 10.1016/j.jvs.2018.11.023. - DOI - PubMed
    1. Singh S.K., Desai N.D., Chikazawa G., Tsuneyoshi H., Vincent J., Zagorski B.M., Pen V., Moussa F., Cohen G.N., Christakis G.T., et al. The Graft Imaging to Improve Patency (GRIIP) clinical trial results. J. Thorac. Cardiovasc. Surg. 2010;139:294–301.e1. doi: 10.1016/j.jtcvs.2009.09.048. - DOI - PubMed
    1. Mangano A., Masrur M.A., Bustos R., Chen L.L., Fernandes E., Giulianotti P.C. Near-Infrared Indocyanine Green-Enhanced Fluorescence and Minimally Invasive Colorectal Surgery: Review of the Literature. Surg. Technol. Int. 2018;33:77–83. - PubMed
    1. Whiting P.F., Rutjes A.W., Westwood M.E., Mallett S., Deeks J.J., Reitsma J.B., Leeflang M.M., Sterne J.A., Bossuyt P.M.M., The QUADAS-2 Group QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies. Ann. Intern. Med. 2011;155:529–536. doi: 10.7326/0003-4819-155-8-201110180-00009. - DOI - PubMed

LinkOut - more resources