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Review
. 2021 May 20;26(10):3042.
doi: 10.3390/molecules26103042.

Bioactive Components of Salvia and Their Potential Antidiabetic Properties: A Review

Aswir Abd Rashed  1 , Devi-Nair Gunasegavan Rathi  1
Affiliations
Review

Bioactive Components of Salvia and Their Potential Antidiabetic Properties: A Review

Aswir Abd Rashed et al. Molecules. .

Abstract

The utilization of therapeutic plants is expanding around the globe, coupled with the tremendous expansion of alternative medicine and growing demand in health treatment. Plants are applied in pharmaceuticals to preserve and expand health-physically, mentally and as well as to treat particular health conditions and afflictions. There are more than 600 families of plants identified so far. Among the plants that are often studied for their health benefit include the genus of Salvia in the mint family, Lamiaceae. This review aims to determine the bioactive components of Salvia and their potential as antidiabetic agents. The search was conducted using three databases (PubMed, EMBASE and Scopus), and all relevant articles that are freely available in the English language were extracted within 10 years (2011-2021). Salvia spp. comprises many biologically active components that can be divided into monoterpenes, diterpenes, triterpenes, and phenolic components, but only a few of these have been studied in-depth for their health benefit claims. The most commonly studied bioactive component was salvianolic acids. Interestingly, S. miltiorrhiza is undoubtedly the most widely studied Salvia species in terms of its effectiveness as an antidiabetic agent. In conclusion, we hope that this review stimulates more studies on bioactive components from medicinal plants, not only on their potential as antidiabetic agents but also for other possible health benefits.

Keywords: Salvia; antidiabetic; bioactive components; human health.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Hydrolysis of starch to glucose as catalyzed by α-amylase and α-glucosidase (adapted from [23]).
Figure 2
Figure 2
The chemical structures of several main chemical constituents (source: [58,59,60,61,62,63,64,65,66,67,68]).
Figure 3
Figure 3
Schematic diagram representing the development of diabetic nephropathy, cardiomyopathy and nephropathy (adapted from [99,100]).
Figure 4
Figure 4
The schematic diagram of PINK1/Parkin-mediated mitophagy (adapted from [101]).
See this image and copyright information in PMC

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References

    1. American Diabetes Association Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2009;32:S62–S67. doi: 10.2337/dc09-S062. - DOI - PMC - PubMed
    1. Afrisham R., Aberomand M., Ghaffari M.A., Siahpoosh A., Jamalan M. Inhibitory Effect of Heracleum persicum and Ziziphus jujuba on Activity of Alpha-Amylase. J. Bot. 2015;2015:824683. doi: 10.1155/2015/824683. - DOI
    1. Kooti W., Moradi M., Aliakbari S., Sharafi-Ahvazi N., Asadi-Samani M., Ashtary-Larky D. Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review. J. Herb. Med. Pharmacol. 2015;4:1–9.
    1. Chen S.T., Dou J., Temple R., Agarwal R., Wu K.M., Walker S. New therapies from old medicines. Nat. Biotechnol. 2008;26:1077–1083. doi: 10.1038/nbt1008-1077. - DOI - PubMed
    1. Pelkonen O., Xu Q., Fan T.-P. Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality? J. Tradit. Complement. Med. 2014;4:1–7. doi: 10.4103/2225-4110.124323. - DOI - PMC - PubMed

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