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Review
. 2021 May 16;9(2):23.
doi: 10.3390/proteomes9020023.

Current State of SLC and ABC Transporters in the Skin and Their Relation to Sweat Metabolites and Skin Diseases

Marcus M. K. Nielsen  1 , Eva Aryal  1 , Elnaz Safari  2 , Biljana Mojsoska  3 , Håvard Jenssen  3 , Bala Krishna Prabhala  1
Affiliations
Review

Current State of SLC and ABC Transporters in the Skin and Their Relation to Sweat Metabolites and Skin Diseases

Marcus M. K. Nielsen et al. Proteomes. .

Abstract

With a relatively large surface area (2 m2) and 15% of total body mass, the skin forms the largest organ of the human body. The main functions of the skin include regulation of body temperature by insulation or sweating, regulation of the nervous system, regulation of water content, and protection against external injury. To perform these critical functions, the skin encodes genes for transporters responsible for the cellular trafficking of essential nutrients and metabolites to maintain cellular hemostasis. However, the knowledge on the expression, regulation, and function of these transporters is very limited and needs more work to elucidate how these transporters play a role both in disease progression and in healing. Furthermore, SLC and ABC transporters are understudied, and even less studied in skin. There are sparse reports on relation between transporters in skin and sweat metabolites. This mini review focuses on the current state of SLC and ABC transporters in the skin and their relation to sweat metabolites and skin diseases.

Keywords: ABC transporters; KNIME; SLC transporters; skin diseases; skin transporters; sweat metabolites.

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Conflict of interest statement

There are no potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of skin. Created in biorender.com (accessed on 29 March 2021).
Figure 2
Figure 2
Schematic representation of the secondary structure of ABC transporters. N terminus in orange, C terminus in blue, NBD stands for nucleotide-binding domain. Created with biorender.com (accessed on 29 March 2021).
Figure 3
Figure 3
Schematic representation of the secondary structure of SLC transporters. N terminus in orange, C terminus in blue. Created with biorender.com (accessed on 29 March 2021).
Figure 4
Figure 4
Schematic representation of the three types of SLC transporters. Created with biorender.com (accessed on 29 March 2021).
Figure 5
Figure 5
KNIME workflow used to map the co-occurrences of sweat metabolites vs. skin SLC and ABC transporters. Customized from original. https://www.knime.com/term-coocurrence-heatmap-example (accessed on 15 March 2021).
Figure 6
Figure 6
Co-occurrences of sweat metabolites with ABC transporter proteins.
Figure 7
Figure 7
Co-occurrences of sweat metabolites with SLC transporter proteins.
See this image and copyright information in PMC

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