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. 2021 May 12;18(10):5114.
doi: 10.3390/ijerph18105114.

Interrupted Time Series Analysis of Changes in Zolpidem Use Due to Media Broadcasts

Bo-Ram Yang  1 , Kyu-Nam Heo  2 , Yun Mi Yu  3   4 , Ga-Bin Yeom  5 , Hye Duck Choi  5 , Ju-Yeun Lee  2 , Young-Mi Ah  5
Affiliations

Interrupted Time Series Analysis of Changes in Zolpidem Use Due to Media Broadcasts

Bo-Ram Yang et al. Int J Environ Res Public Health. .

Abstract

Media has become a major source of information on health and plays a role in the decision-making process on health topics. We aimed to evaluate the association between zolpidem use and media broadcasts that reported the suicide risk. We obtained the data of adult outpatients who have been prescribed zolpidem or other hypnotics from the National Patient Sample database (2015-2017). We evaluated the change in zolpidem or other hypnotic prescription trends based on the prescription rate and average daily prescribed dose before and after July 2016, using interrupted time series analysis. A total of 129,787 adult patients had at least one zolpidem prescription in 3 years. The prescription rate of zolpidem after the broadcast decreased significantly by 0.178% (95% confidence interval (CI): -0.214, -0.142), whereas that of other hypnotic users did not differ from that before the broadcast (-0.020%, 95% CI: -0.088, 0.047). However, the trends in the prescription rate before and after the broadcast did not differ for zolpidem and other hypnotics. Broadcasting medication safety through major public media could have an effect on medication use. After broadcasting about the suicide risk of zolpidem, its overall prescription rate decreased immediately, but the trend was not changed.

Keywords: broadcast; interrupted time series analysis; medication safety; zolpidem.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Overall monthly prescription rate or average daily prescribed dose of zolpidem or other hypnotics, 2015–2017. DDD; Defined daily dose.
Figure 1
Figure 1
Overall monthly prescription rate or average daily prescribed dose of zolpidem or other hypnotics, 2015–2017. DDD; Defined daily dose.
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