Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May 8;11(5):387.
doi: 10.3390/jpm11050387.

Hormone Receptor Expression Variations in Normal Breast Tissue: Preliminary Results of a Prospective Observational Study

Giacomo Santandrea  1   2 , Chiara Bellarosa  3 , Dino Gibertoni  4 , Maria C Cucchi  5 , Alejandro M Sanchez  6 , Gianluca Franceschini  6 , Riccardo Masetti  6 , Maria P Foschini  3
Affiliations

Hormone Receptor Expression Variations in Normal Breast Tissue: Preliminary Results of a Prospective Observational Study

Giacomo Santandrea et al. J Pers Med. .

Abstract

Normal breast tissue undergoes great variations during a woman's life as a consequence of the different hormonal stimulation. The purpose of the present study was to examine the hormonal receptor expression variations according to age, menstrual cycle, menopausal state and body mass index. To this purpose, 49 tissue samples of normal breast tissue, obtained during surgery performed for benign and malignant conditions, were immunostained with Estrogen (ER), Progesterone (PR) and Androgen receptors (AR). In addition, Ki67 and Gross Cystic Disease Fluid Protein were studied. The data obtained revealed a great variability of hormone receptor expression. ER and AR generally increased in older and post-menopausal women, while young women presented a higher proliferative rate, evaluated with Ki67. PR increase was observed in women with BMI higher than 25. The different hormonal receptor expression could favor the development of breast cancer.

Keywords: breast cancer; breast pathology; hormone expression; hormone receptor; normal breast.

PubMed Disclaimer

Conflict of interest statement

Disclosure of financial interests and potential conflicts of interest. MPF received grants from Roche, Devicor Mammotome as support for course organization and participation, and from MSD and Biocartis as speaker fee. All the remaining authors submitting this manuscript confirm and attest that they have no conflict of interest. There are no source of support in any form nor funding for this work. There are no financial relation-ships for this work.

References

    1. Lteif A., Javed A. Development of the Human Breast. Semin. Plast. Surg. 2013;27:005–012. doi: 10.1055/s-0033-1343989. - DOI - PMC - PubMed
    1. Longacre T.A., Bartow S.A. A Correlative Morphologic Study of Human Breast and Endometrium in the Menstrual Cycle. Am. J. Surg. Pathol. 1986;10:382–393. doi: 10.1097/00000478-198606000-00003. - DOI - PubMed
    1. American Cancer Society . Breast Cancer Facts & Figure 2015–Figure 2016. American Cancer Society; Atlanta, GA, USA: 2015.
    1. Howlader N.A., Krapcho M., Miller D. SEER Cancer Statistics Review, 1975–2014; National Cancer Institute: Bethesda, MD, USA. [(accessed on 2 February 2021)]; Available online: https://seer.cancer.gov/csr/1975_2014/
    1. Daly A., Rolph R., Cutress R., Copson E.R. A Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer. Breast Cancer Targets Ther. 2021;13:241–257. doi: 10.2147/BCTT.S268401. - DOI - PMC - PubMed