Impact of Intrinsic Muscle Weakness on Muscle-Bone Crosstalk in Osteogenesis Imperfecta

doi:10.3390/ijms22094963

Review

. 2021 May 7;22(9):4963.

doi: 10.3390/ijms22094963.

Impact of Intrinsic Muscle Weakness on Muscle-Bone Crosstalk in Osteogenesis Imperfecta

Victoria L Gremminger¹, Charlotte L Phillips^{1

2}

Affiliations

¹ Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA.
² Department of Child Health, University of Missouri, Columbia, MO 65212, USA.

PMID: 34066978
PMCID: PMC8125032
DOI: 10.3390/ijms22094963

Review

Impact of Intrinsic Muscle Weakness on Muscle-Bone Crosstalk in Osteogenesis Imperfecta

Victoria L Gremminger et al. Int J Mol Sci. 2021.

. 2021 May 7;22(9):4963.

doi: 10.3390/ijms22094963.

Authors

Victoria L Gremminger¹, Charlotte L Phillips^{1

2}

Affiliations

¹ Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA.
² Department of Child Health, University of Missouri, Columbia, MO 65212, USA.

PMID: 34066978
PMCID: PMC8125032
DOI: 10.3390/ijms22094963

Abstract

Bone and muscle are highly synergistic tissues that communicate extensively via mechanotransduction and biochemical signaling. Osteogenesis imperfecta (OI) is a heritable connective tissue disorder of severe bone fragility and recently recognized skeletal muscle weakness. The presence of impaired bone and muscle in OI leads to a continuous cycle of altered muscle-bone crosstalk with weak muscles further compromising bone and vice versa. Currently, there is no cure for OI and understanding the pathogenesis of the skeletal muscle weakness in relation to the bone pathogenesis of OI in light of the critical role of muscle-bone crosstalk is essential to developing and identifying novel therapeutic targets and strategies for OI. This review will highlight how impaired skeletal muscle function contributes to the pathophysiology of OI and how this phenomenon further perpetuates bone fragility.

Keywords: mechanotransduction; muscle bone crosstalk; musculoskeletal disorders; myokine; osteogenesis imperfecta; osteokine.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Marini J.C., Forlino A., Bächinger H.P., Bishop N.J., Byers P.H., De Paepe A., Fassier F., Fratzl-Zelman N., Kozloff K.M., Krakow D., et al. Osteogenesis imperfecta. Nat. Rev. Dis. Prim. 2017;3:17052. doi: 10.1038/nrdp.2017.52. - DOI - PubMed
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1. Gentry B.A., Ferreira J.A., McCambridge A.J., Brown M., Phillips C.L. Skeletal muscle weakness in osteogenesis imperfecta mice. Matrix Biol. 2010;29:638–644. doi: 10.1016/j.matbio.2010.06.006. - DOI - PMC - PubMed
1. Veilleux L.N., Darsaklis V.B., Montpetit K., Glorieux F.H., Rauch F. Muscle Function in Osteogenesis Imperfecta Type IV. Calcif. Tissue Int. 2017;101:362–370. doi: 10.1007/s00223-017-0287-y. - DOI - PubMed
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[1] Marini J.C., Forlino A., Bächinger H.P., Bishop N.J., Byers P.H., De Paepe A., Fassier F., Fratzl-Zelman N., Kozloff K.M., Krakow D., et al. Osteogenesis imperfecta. Nat. Rev. Dis. Prim. 2017;3:17052. doi: 10.1038/nrdp.2017.52. - DOI - PubMed

[2] Marini J.C., Forlino A., Bächinger H.P., Bishop N.J., Byers P.H., De Paepe A., Fassier F., Fratzl-Zelman N., Kozloff K.M., Krakow D., et al. Osteogenesis imperfecta. Nat. Rev. Dis. Prim. 2017;3:17052. doi: 10.1038/nrdp.2017.52. - DOI - PubMed

[3] Marom R., Rabenhorst B.M., Morello R. Osteogenesis imperfecta: An update on clinical features and therapies. Eur. J. Endocrinol. 2020;183:R95–R106. doi: 10.1530/EJE-20-0299. - DOI - PMC - PubMed

[4] Marom R., Rabenhorst B.M., Morello R. Osteogenesis imperfecta: An update on clinical features and therapies. Eur. J. Endocrinol. 2020;183:R95–R106. doi: 10.1530/EJE-20-0299. - DOI - PMC - PubMed

[5] Gentry B.A., Ferreira J.A., McCambridge A.J., Brown M., Phillips C.L. Skeletal muscle weakness in osteogenesis imperfecta mice. Matrix Biol. 2010;29:638–644. doi: 10.1016/j.matbio.2010.06.006. - DOI - PMC - PubMed

[6] Gentry B.A., Ferreira J.A., McCambridge A.J., Brown M., Phillips C.L. Skeletal muscle weakness in osteogenesis imperfecta mice. Matrix Biol. 2010;29:638–644. doi: 10.1016/j.matbio.2010.06.006. - DOI - PMC - PubMed

[7] Veilleux L.N., Darsaklis V.B., Montpetit K., Glorieux F.H., Rauch F. Muscle Function in Osteogenesis Imperfecta Type IV. Calcif. Tissue Int. 2017;101:362–370. doi: 10.1007/s00223-017-0287-y. - DOI - PubMed

[8] Veilleux L.N., Darsaklis V.B., Montpetit K., Glorieux F.H., Rauch F. Muscle Function in Osteogenesis Imperfecta Type IV. Calcif. Tissue Int. 2017;101:362–370. doi: 10.1007/s00223-017-0287-y. - DOI - PubMed

[9] Veilleux L.N., Rauch F. Muscle-Bone Interactions in Pediatric Bone Diseases. Curr. Osteoporos. Rep. 2017;15:425–432. doi: 10.1007/s11914-017-0396-6. - DOI - PubMed

[10] Veilleux L.N., Rauch F. Muscle-Bone Interactions in Pediatric Bone Diseases. Curr. Osteoporos. Rep. 2017;15:425–432. doi: 10.1007/s11914-017-0396-6. - DOI - PubMed

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Impact of Intrinsic Muscle Weakness on Muscle-Bone Crosstalk in Osteogenesis Imperfecta

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Impact of Intrinsic Muscle Weakness on Muscle-Bone Crosstalk in Osteogenesis Imperfecta

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