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Review
. 2021 May 22;19(6):296.
doi: 10.3390/md19060296.

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Tae-Hee Kim  1 , Seong-Yeong Heo  2 , Gun-Woo Oh  2 , Soo-Jin Heo  3   4 , Won-Kyo Jung  1   2
Affiliations
Review

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Tae-Hee Kim et al. Mar Drugs. .

Abstract

Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A2A receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.

Keywords: biomedical engineering; marine organisms; polydeoxyribonucleotide.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A wide range of therapeutic applications in the field of PDRN.
Figure 2
Figure 2
The annual number of articles about the biological effect of PDRN from 2016 to 2020 (n = 70).
Figure 3
Figure 3
The number of articles about PDRN from 2016 to 2020 (n = 70). (A) Extraction sources, (B) Companies provided, (C) kind of study, and (D) pharmaceutical activities of PDRN.
See this image and copyright information in PMC

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