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Review
. 2021 May 17;10(5):611.
doi: 10.3390/pathogens10050611.

Neonatal SARS-CoV-2 Infection: Practical Tips

Cinzia Auriti  1 , Domenico Umberto De Rose  1 , Vito Mondì  2 , Ilaria Stolfi  3 , Chryssoula Tzialla  4 , On Behalf Of The Study Group Of Neonatal Infectious Diseases
Affiliations
Review

Neonatal SARS-CoV-2 Infection: Practical Tips

Cinzia Auriti et al. Pathogens. .

Abstract

The recent viral pandemic in Wuhan, Hubei, China has led to the identification of a new species of beta-coronavirus, able to infect humans, the 2019-nCoV, later named SARS-CoV-2. SARS-CoV-2 causes a clinical syndrome named COVID-19, which presents with a spectrum of symptoms ranging from mild upper respiratory tract infection to severe pneumonia, with acute respiratory distress syndrome and frequent death. All age groups are susceptible to the infection, but children, especially infants, seem to be partially spared, having a more favorable clinical course than other age groups. There is currently no clear evidence showing vertical transmission and intrauterine SARS-CoV-2 infection in fetuses of women developing COVID-19 pneumonia in late pregnancy, and even if transmission is possible, the SARS-CoV2 positivity of the mother does not require delivery by caesarean section, does not contraindicate the management of the infant in rooming-in and allows breastfeeding. This review provides an overview on the biology of the virus, on the pathogenesis of the infection, with particular attention to pregnancy and neonatal age, on the clinical presentation of infection in newborns and young infants and summarizes the international recommendations currently available on the clinical care of neonates with SARS-CoV2 infection or at risk of catching the virus. The main objective of the review is to provide an update especially focused to the clinical management of COVID-19 infection in the perinatal and neonatal age.

Keywords: COVID-19; SARS-CoV-2; infants; neonates; pregnancy; pregnant women.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structure of SARS-CoV-2 virus.
Figure 2
Figure 2
SARS-CoV-2 entry into host cells through its receptor-binding domain (RBD) and its affinity to human receptor ACE2.
See this image and copyright information in PMC

References

    1. Li F. Structure, function, and evolution of coronavirus spike proteins. Annu. Rev. Virol. 2016;3:237–261. doi: 10.1146/annurev-virology-110615-042301. - DOI - PMC - PubMed
    1. Su S., Wong G., Shi W., Liu J., Lai A.C., Zhou J., Liu W., Bi Y., Gao G.F. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol. 2016;24:490–502. doi: 10.1016/j.tim.2016.03.003. - DOI - PMC - PubMed
    1. Cui J., Li F., Shi Z.-L. Origin and evolution of pathogenic coronaviruses. Nat. Rev. Microbiol. 2019;17:181–192. doi: 10.1038/s41579-018-0118-9. - DOI - PMC - PubMed
    1. Setti L., Passarini F., De Gennaro G., Barbieri P., Perrone M.G., Borelli M., Palmisani J., Di Gilio A., Piscitelli P., Miani A. Airborne transmission route of COVID-19: Why 2 meters/6 feet of inter-personal distance could not be enough. Int. J. Environ. Res. Public Health. 2020;17:2932. doi: 10.3390/ijerph17082932. - DOI - PMC - PubMed
    1. Amodio E., Vitale F., Cimino L., Casuccio A., Tramuto F. Outbreak of novel coronavirus (SARS-Cov-2): First evidences from international scientific literature and pending questions. Healthcare. 2020;8:51. doi: 10.3390/healthcare8010051. - DOI - PMC - PubMed

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