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. 2021 May 13;9(5):575.
doi: 10.3390/healthcare9050575.

Long-COVID Syndrome? A Study on the Persistence of Neurological, Psychological and Physiological Symptoms

Graziella Orrù  1 , Davide Bertelloni  1 , Francesca Diolaiuti  1 , Federico Mucci  2 , Mariagrazia Di Giuseppe  1 , Marco Biella  1 , Angelo Gemignani  1 , Rebecca Ciacchini  1 , Ciro Conversano  1
Affiliations

Long-COVID Syndrome? A Study on the Persistence of Neurological, Psychological and Physiological Symptoms

Graziella Orrù et al. Healthcare (Basel). .

Abstract

Background: Emerging aspects of the Covid-19 clinical presentation are its long-term effects, which are characteristic of the so-called "long COVID". The aim of the present study was to investigate the prevalence of physical, psychological, and sleep disturbances and the quality of life in the general population during the ongoing pandemic.

Methods: This study, based on an online survey, collected demographic data, information related to COVID-19, sleep disturbances, and quality of life data from 507 individuals. The level of sleep disturbances and quality of life was assessed through the Insomnia Severity Index (ISI) and the EuroQol-5D (EQ-5D), respectively.

Results: In total, 507 individuals (M = 91 and F = 416 women) completed the online survey. The main symptoms associated with "long COVID" were headache, fatigue, muscle aches/myalgia, articular pains, cognitive impairment, loss of concentration, and loss of smell. Additionally, the subjects showed significant levels of insomnia (p < 0.05) and an overall reduced quality of life (p < 0.05).

Conclusions: The results of the study appear in line with recent publications, but uncertainty regarding the definition and specific features of "long COVID" remains. Further studies are needed in order to better define the clinical presentation of the "long COVID" condition and related targeted treatments.

Keywords: COVID-19; insomnia; long COVID; long-haul COVID; quality of life.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Percentages of symptoms reported by subjects in different COVID-19 conditions. The symptoms were divided into sub-categories: Musculoskeletal symptoms (A); Neurological symptoms (B); Symptoms regarding the ear, nose, throat, and sight (C); Cardiovascular symptoms (D); Dermatological symptoms (E); Gastrointestinal symptoms (F); Respiratory symptoms (G); Psychological/Psychiatric symptoms (H).
Figure 1
Figure 1
Percentages of symptoms reported by subjects in different COVID-19 conditions. The symptoms were divided into sub-categories: Musculoskeletal symptoms (A); Neurological symptoms (B); Symptoms regarding the ear, nose, throat, and sight (C); Cardiovascular symptoms (D); Dermatological symptoms (E); Gastrointestinal symptoms (F); Respiratory symptoms (G); Psychological/Psychiatric symptoms (H).
Figure 2
Figure 2
The mean values of the scores indicated by the subjects regarding their insomnia (ISI score) are reported, stratified by COVID-19 status.
Figure 3
Figure 3
Mean values of the scores indicated by the subjects regarding their quality of life, classified according to the COVID-19 status.
See this image and copyright information in PMC

References

    1. Baud D., Qi X., Nielsen-Saines K., Musso D., Pomar L., Favre G. Real estimates of mortality following COVID-19 infection. Lancet Infect. Dis. 2020;20:773. doi: 10.1016/S1473-3099(20)30195-X. - DOI - PMC - PubMed
    1. Wang Y., Kala M.P., Jafar T.H. Factors associated with psychological distress during the coronavirus disease 2019 (COVID-19) pandemic on the predominantly general population: A systematic review and meta-analysis. PLoS ONE. 2020;15:e0244630. doi: 10.1371/journal.pone.0244630. - DOI - PMC - PubMed
    1. Ruan Q., Yang K., Wang W., Jiang L., Song J. Correction to: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46:1294–1297. doi: 10.1007/s00134-020-06028-z. - DOI - PMC - PubMed
    1. Sivan M., Halpin S., Hollingworth L., Snook N., Hickman K., Clifton I.J. Development of an integrated rehabilitation pathway for individuals recovering from COVID-19 in the community. J. Rehabil. Med. 2020;52:jrm00089. doi: 10.2340/16501977-2727. - DOI - PubMed
    1. Ahmad I., Rathore F.A. Neurological manifestations and complications of COVID-19: A literature review. J. Clin. Neurosci. 2020;77:8–12. doi: 10.1016/j.jocn.2020.05.017. - DOI - PMC - PubMed

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