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. 2021 May 10;10(9):2042.
doi: 10.3390/jcm10092042.

Impact of Kidney Failure on the Severity of COVID-19

Dorota Zarębska-Michaluk  1 , Jerzy Jaroszewicz  2 , Magdalena Rogalska  3 , Beata Lorenc  4 , Marta Rorat  5   6 , Anna Szymanek-Pasternak  5 , Anna Piekarska  7 , Aleksandra Berkan-Kawińska  7 , Katarzyna Sikorska  8 , Magdalena Tudrujek-Zdunek  9 , Barbara Oczko-Grzesik  2 , Beata Bolewska  10 , Piotr Czupryna  11 , Dorota Kozielewicz  12 , Justyna Kowalska  13 , Regina Podlasin  14 , Krzysztof Kłos  15 , Włodzimierz Mazur  16 , Piotr Leszczyński  17   18 , Bartosz Szetela  19 , Katarzyna Reczko  1 , Robert Flisiak  3
Affiliations

Impact of Kidney Failure on the Severity of COVID-19

Dorota Zarębska-Michaluk et al. J Clin Med. .

Abstract

Background: Patients with kidney failure are at an increased risk of progression to a severe form of coronavirus disease 2019 (COVID-19) with high mortality. The current analysis was aimed to assess the impact of renal failure on the severity of COVID-19 and identify the risk factors of the fatal outcome in this population.

Methods: The analysis included patients from the SARSTer database, a national real-world study evaluating treatment for COVID-19 in 30 Polish centers. Data were completed retrospectively and submitted online.

Results: A total of 2322 patients were included in the analysis. Kidney failure was diagnosed in 455 individuals (19.65%), of whom 373 presented moderate stage and 82 patients, including 14 dialysis individuals, presented severe renal failure. Patients with kidney failure were significantly older and demonstrated a more severe course of COVID-19. The age, baseline SpO2, the ordinal scale of 4 and 5, neutrophil and platelet count, estimated glomerular filtration rate, and C-reactive protein concentration as well as malignancy and arterial hypertension were the independent predictors of 28-day mortality in logistic regression analysis.

Conclusions: Underlying kidney disease in patients with COVID-19 is among the leading factors associated with a higher risk of severe clinical presentation and increased mortality rate.

Keywords: COVID-19; SARS-CoV-2; kidney failure; mortality.

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Conflict of interest statement

D.Z.-M. reports personal fees from Gilead and Abbvie, outside the submitted work. R.F. reports grants from Abbvie, Gilead, Merck, personal fees from Gilead, Abbvie, Merck, Roche, and non-financial support from Abbvie, Gilead, and Merck outside the submitted work. J.J. reports personal fees from Gilead, Abbvie, Bausch Health, Merck, Promed, Roche, and non-financial support from Abbvie, Gilead, and Merck outside the submitted work. D.K. reports personal fees from Gilead and Abbvie outside the submitted work. J.K. reports personal fees from Gilead, Merck, ViiV, Janssen outside the submitted work. R.P. reports personal fees from Gilead outside the submitted work. W.M. reports grants and personal fees from Gilead, Abbvie, Abbott, Roche, Janssen outside the submitted work. P.L. reports grants and personal fees from Abbvie, Roche, UCB, Lilly, Novartis, BMS, Amgen, Janssen, Abivax, Viela-Bio outside the submitted work. BS reports grants from Abbvie, Gilead, Janssen, personal fees from Gilead, Abbvie, Janssen outside the submitted work. MRog, B.L., MRor, A.S.-P, A.P., A.B.-K., B.B., M.T.-Z., D.K., K.K., K.R., P.C., B.O.-G., K.S. declare no competing interests.

Figures

Figure 1
Figure 1
Kaplan–Meier survival curves of the CKD groups dependent on the eGFR.
See this image and copyright information in PMC

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