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. 2021 May 14;11(5):1402.
doi: 10.3390/ani11051402.

Effect of One-Day Delaying CIDR Administration in 5-Day Cosynch Protocol in Dairy Heifers

Sükrü Metin Pancarci  1 , Örsan Güngör  2 , Osman Harput  3 , Oguz Calisici  4
Affiliations

Effect of One-Day Delaying CIDR Administration in 5-Day Cosynch Protocol in Dairy Heifers

Sükrü Metin Pancarci et al. Animals (Basel). .

Abstract

Effect of one-day delaying progesterone administration at the beginning of 5-day Cosynch protocol was investigated in Holstein heifers for the first artificial insemination (AI). Heifers received a synchronized ovulation and timed AI (TAI) with CIDR inserted on day (d) 0 (CIDR-5; n = 206) or d 1 (CIDR-4; n = 192). In both group, GnRH was administered on d 0 followed by a single PGF2α injection and CIDR removal five days later from GnRH. On d 8, TAI and GnRH administration were concurrently conducted. Heifers detected in estrus up to 24 h prior to TAI were inseminated without GnRH administration. Rates of ovulation, accessory CL formation and new dominant follicle development following initial GnRH injection did not differ between groups. P/AI did not differ between CIDR-4 (44.3%, [85/192]) and CIDR-5 (51.9%, [107/206]) groups, respectively. Pregnancy per AI (P/AI) was significantly (p < 0.01) declined as heifers' age (12-13, 14, 15, 16 and17-21 months) proceeded in CIDR-4 group (55.6%, 52.1%, 37.9%, 35.7%, 32.4%) compared to those in CIDR-5 group (60.0%, 50.0%, 53.9%, 51.5%, 46.2%) respectively. In conclusion, there is no benefit for delaying CIDR administration in 5-day Cosynch protocol in dairy heifers. However, higher P/AI in CIDR-5 group in older heifers can be considered for reproductive management.

Keywords: Cosynch; TAI; dairy heifer; follicle development; pregnancy; progesterone.

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Conflict of interest statement

The funders had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Diagrammatic representation of experimental design of treatments. CIDR, controlled internal drug release; TAI, timed artificial insemination; PD, Pregnancy diagnosis. Heifers at five locations were assigned randomly to receive a synchronization of ovulation and TAI. Both treatments consisted of a GnRH injection on day 0. CIDR inserted on day (d) 0 (CIDR-5; n = 206) or d 1 (CIDR-4; n = 192) of synchronization program. On d 8, TAI and GnRH administration were concurrently conducted. Heifers detected in estrus up to 24 h prior to TAI were inseminated without GnRH administration (AIE).
Figure 2
Figure 2
Development of original CL, accessory CL and new wave dominant follicle during experimental period.
Figure 3
Figure 3
The distribution of AI at detected estruses (AIE, black bars) and timed artificial insemination (TAI, gray bars) in CIDR-4 and CIDR-5 groups. Rate of AIE was tended (p < 0.09) to be higher in CIDR-5 group than that in CIDR-4 group.
Figure 4
Figure 4
Significant (p < 0.01) interaction effect of treatment (CIDR-4 vs. CIDR-5) by age of heifer indicates lower pregnancy per AI in CIDR-4 (gray bars) group as heifers age increased compared to CIDR-5 (black bars) group.
Figure 5
Figure 5
Significant (p < 0.05) interaction effect of treatment (CIDR-4 vs. CIDR-5) by presynchronization indicates lower pregnancy per AI in heifers without presynchronization (gray bars) compared to those with presynchronization (black bars) in CIDR-4 group. While pregnancy per AI in heifers with or without presynchronization were similar in CIDR-5 group.
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